Isopropyl (3-Chlorophenyl)Carbamate (3-氯苯基)氨基甲酸异丙酯

CAS 101-21-3 MFCD00037108

化学结构图

101-21-3
SMILES: CC(C)OC(=O)Nc1cccc(Cl)c1

化学属性

Mol. FormulaC10H12ClNO2
Mol. Weight213.66
Melting Point36-38°C
Boiling Point248°C at 760 mmHg
Density1.18
Solubility0.009 G/100 ML VERY POOR
Flash Point153.3°C
Appearance crystalline

别名和识别编码

Chemical NameIsopropyl (3-Chlorophenyl)Carbamate
MDL NumberMFCD00037108
CAS Number101-21-3
Synonym Chlorpropham {LY} Chlorpropham {} {LY} Chlorpropham {} {} {LY} Chlorpropham {} {} {} {LY} Chlorpropham {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorpropham {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID2728
Beilstein Registry Number2211397
EC Number202-925-7
Chemical Name Translation(3-氯苯基)氨基甲酸异丙酯
Merck Number13,2206
Wiswesser Line NotationGR CMVOY1&1
InChIInChI=1S/C10H12ClNO2/c1-7(2)14-10(13)12-9-5-3-4-8(11)6-9/h3-7H,1-2H3,(H,12,13)
Canonical SMILESO=C(NC1=CC=CC(Cl)=C1)OC(C)C
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分类

  • {SNA} All alphabetically sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, C, CH, Carbanilate, Chromatography, Environmental Standards, Herbicides, Pesticides & Metabolites
  • {SNA} Amides, Building Blocks, C8 to C20+, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
  • {SNA} 2005/70/EU, All alphabetically sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, C, CH, Carbanilate,
  • {Chemicalbook} 农药: 除草剂: 氨基甲酸酯类除草剂
  • {SNA} 2005/7

产品应用

  • 有丝分裂毒药;抑制植物代谢。
  • 农业上用作选择性芽前除草剂,防除胡萝卜、韭葱、洋葱等作物中的杂草。

相关文献及参考

  • Short: EINECS
  • Short: IV/8A
  • Merck:13,2206

安全信息

GHS Symbol
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P301+P312+P330
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
  • H302 Harmful if swallowed 吞食有害
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H332 Harmful if inhaled 吸入有害
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H312 Harmful in contact with skin 皮肤接触有害
WGK Germany2
RTECSFD8050000
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter dust mask type N95 (US), Eyeshields, Gloves
Signal word Danger Warning
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
Hazard Codes Xn,N,F F,Xn Xn,N
Risk Statements
  • R36 Irritating to eyes 刺激眼睛
  • R11 Highly flammable 非常易燃
  • R22 Harmful if swallowed 吞咽有害
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R51/53
Storage condition 2-8°C {LY} 2-8°C APPROX 4°C Store at room temperature {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
UN Number UN 3077 9/PG 3
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   12,355,1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Bird - duck
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMCHA2 Farm Chemicals Handbook.  (Meister Pub., 37841 Euclid Ave.,
   Willoughy, OH 44094)  Volume(issue)/page/year: -,C73,1991

{h

TYPE OF TEST            : LD50 - Lethal dose,

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  V

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PAREAQ Pharmacological Reviews.  (Williams & Wilkins, 428 E. Preston St.,
   Baltimore, MD 21202) V.1-    1949-  Volume(issue)/page/year: 14,225,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-    1849-
   Volume(issue)/page/year: 175,496,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUT

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 100 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,414,1981

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 25 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,468,1981

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 2500 ug/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,638,1981

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 31500 ug/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volum

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 30 mg/L
REFERENCE :
   ABILAE Archives de Biologie (1880-1985).  (Liege, Belgium)  V.1-96(1),
   1880-1985.  Volume(issue)/page/year: 92,367,1981

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 4 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,528,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3 gm/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   REPTED Reproductive Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1987-  Volume(issue)/page/year:
   11,697,1997

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 9 gm/kg
SEX/DURATION            : female 6-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB223-160

其他信息

  • 1000μg/ml,溶于吹扫-捕集甲醇溶液中
  • 急性毒性:口服- 大鼠 LD50: 1200 毫克/ 公斤
  • 毒性分级:中毒
  • Sigma Aldrich:101-21-3(sigmaaldrich)
  • 急救治疗:用阿托品0.5-2mg口服或肌肉注射,重者加用肾上素。禁用解磷定,氯磷定,双复磷,吗啡
  • 用途一:用于抑制马铃薯贮藏期发芽
  • 灭火剂:干粉、泡沫、砂土
  • 中毒症状:对眼和皮肤有刺激作用,浓度大时轻度抑制胆碱酯酶。
  • MSDS 信息:间氯苯氨基甲酸异丙酯(101-21-3).msds
  • color:light tan
  • 毒性:大鼠急性经口LD 50 为5000~7500mg/kg(原药为4200mg/kg),兔急性经皮LD 50 >2000mg/kg。对眼睛稍有刺激性,对皮肤无刺激性。动物试验未见致畸、致突变作用,大鼠慢性毒性试验和致癌作用试验无作用剂量为每天30mg/kg。
  • 用途三:选择性芽前除草剂,防除胡萝卜、韭葱、洋葱等作物中的杂草
  • 溶解度(25°C):水中89mg/L,煤油中100g/L,可与醇类、芳香烃及大多数有机溶剂混溶。
  • 上游原料:氯甲酸异丙酯 --> 间氯苯异氰酸酯
  • 可燃性危险特性:燃烧产生有毒氮氧化物和氯化物气体
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 用途二:既是植物生长调节剂又是除草剂。具有抑制β-淀粉酶活性,抑制植物RNA、蛋白质的合成,干扰氧化磷酸化和光合作用,破坏细胞分裂,因而能显著地抑制马铃薯贮存时的发芽力。也可用于果树的疏花、疏果。同时氯苯胺灵是一种高度选择性苗前或苗后早期除草剂,药剂被禾本科杂草芽鞘吸收,以植物的根部吸收为主,也可被叶片吸收,在体内向上、向下双向传导,能有效防除小麦、玉米、苜蓿、向日葵、马铃薯、甜菜、大豆、水稻、菜豆、胡萝卜、菠菜、莴苣、洋葱、辣椒等作物地中一年生禾本科杂草和部分阔叶草。 用于马铃薯抑芽,在收获后待损伤自然愈合(约14d以上)和出芽前使用,将药剂混细干土均匀撒于马铃薯上,使用剂量为每吨马铃薯用0.7%粉剂1.4~2.1kg(有效成分9.8~14.7g);或用2.5%粉剂400~600g (有效成分10~15g)。 用于防除的杂草主要有生禾苗、稗草、野燕麦、早熟禾、荠菜、苋、燕麦草、多花黑麦草、繁缕、粟米草、萹蓄、马齿苋、田野菟丝子等。在作物播后苗前进行土壤处理,用0.7%粉剂157~425kg/hm 2 单用或混用,可防除敏感杂草。根据土壤有机质、温度不同,适当增大用量可扩大杀草谱。
  • 类别:农药
  • MOL 文件:101-21-3.mol
  • 方法一:氯苯胺灵可由3-氯苯基异氰酸酯与异丙醇作用制得。或由3-氯苯胺与氯甲酸异丙酯作用制得。
  • 注意事项:吞入时,饮水并导吐. 吸入时,移至新鲜空气处并供氧. 溅入眼中,用大量水冲洗. 如皮肤接触,则用肥皂清洗并用清水冲洗.
  • 职业标准:STEL 2 毫克/ 立方米
  • Decomposition:247 °C
  • 稳定性:低于100℃下稳定,在酸、碱介质中缓慢水解
  • 外观:淡棕色结晶,具有轻微的特殊的气味
  • 可与醇类、芳香烃及大多数有机溶剂混溶,在酸、碱介质中缓慢水解。

系列性分类


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