4,4-Diphenylmethane Diisocyanate 4,4-二苯基甲烷二异氰酸酯

CAS 101-68-8 MFCD00036131

化学结构图

101-68-8
SMILES: O=C=NC1CCC(CC2CCC(N=C=O)CC2)CC1

化学属性

Mol. FormulaC₁₅H₁₀N₂O₂
Mol. Weight250.25
Boiling Point
Density1.22
Melting Point43 - 45°C
Flash Point196°(385°F)
TSCAYes
Solubility溶于丙酮、苯、煤油等。
Stability对热和湿度敏感

别名和识别编码

Chemical Name4,4-Diphenylmethane Diisocyanate
Synonym 1,1'-methylenebis(4-isocyanato)-benzene 1,1’-me 4,4'- 4,4'-Methylenedi(phenyl isocyanate) 4,4'-Diphenylmethane diisocyanate 4,4'-Methylenebis(phenyl isocyanate) 4,​4'-​Methylenebis(phenyl Isocyanate) Diphenylmethan-4,4'-diisocyanate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {uni_hamburg} methylenebis {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {uni_hamburg} isocyanic acid, methylenedi-p-phenylene ester {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number101-68-8
PubChem Substance ID87567498
EC Number202-966-0
Beilstein Registry Number797662
MDL NumberMFCD00036131
Reaxys-RN797662
Chemical Name Translation4,4-二苯基甲烷二异氰酸酯
Wiswesser Line NotationOCNR D1R DNCO
LabNetwork Molecule IDLN00239787
InChIInChI=1S/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H2
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分类

  • Alpha Sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards, M, MA - MD, Volatiles/ Semivolatiles
  • {SNA} Chemical Biology, Chemical Synthesis, Crosslinkers, Isocyanate Monomers, Linkers and Crosslinkers, Materials Science, Monomers, Polymer Science
  • {SNA} Alpha Sort, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards, M, MA - MD, Volatiles/ Semivolatiles
  • {SNA} Additional

产品应用

  • 用途包括可紫外固化的和含潜伏性催化剂的聚合反应组合?物。

相关文献及参考

  • Short: EINECS
  • Short: IV/20C
  • Beilstein: 13,III,461
  • Short: IV/6
  • Short: IV/8A
  • Short: IV/20B

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H332 Harmful if inhaled 吸入有害
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H351 Suspected of causing cancer 怀疑致癌
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes 6.1 Xn
RTECSNQ9350000
Precautionary statements
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P302+P350
  • P302+P352+P333+P313+P362+P364
  • P304+P340+P310
  • P304+P340+P312
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P308+P311
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
  • P337+P313
  • P342+P311
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Storage condition 0-10 0-10°C 4 Moisture Sensitive Refrigerator 储存温度 2-8°C 储存温度 2-8°C,充氩保存
UN Number 2206
Safety Statements
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R20 Harmful by inhalation 吸入有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R42/43
  • R48/20
Packing GroupII
Hazard Class6.1
Warnings 危化品目录(2015) 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0516728

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 130 ppb/30M
TOXIC EFFECTS :
   Immunological Including Allergic - increased immune response
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   27,121,1966

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 178 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   43,89,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Human
DOSE/DURATION           : 20 ppb/15M (Continuous)
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 60,131,1992

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 540 mg/L
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 36,37,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 ug/plate
REFERENCE :
   SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu
   1, SF-00290 Helsinki, 29, Finland)  V.1-    1975- Volume(issue)/page/year:
   6,221,1980

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 2170 mg/L
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 36,37,1987

Restrict 危险品

其他信息

  • 外观性质:亮黄色固体。
  • 毒性分级:中毒
  • 有强烈的刺激气味，水中分解，溶于丙酮、苯、煤油、硝基苯。
  • 急性毒性:口服-大鼠 LD50: 9200 毫克/公斤; 口服-小鼠 LD50: 2200 毫克/公斤
  • 类别:有毒物品
  • 下游产品:聚氨酯树脂 --> 聚氨酯硬质泡沫塑料
  • 图谱信息:4,4'-亚甲基双(异氰酸苯酯)(101-68-8)红外图谱(IR1) 4,4'-亚甲基双(异氰酸苯酯)(101-68-8)核磁图( 13 CNMR) 4,4'-亚甲基双(异氰酸苯酯)(101-68-8)质谱(MS) 4,4'-亚甲基双(异氰酸苯酯)(101-68-8)红外图谱(IR2) 4,4'-亚甲基双(异氰酸苯酯)(101-68-8)核磁图( 1 HNMR)
  • 4,4'-亚甲基双(异氰酸苯酯)价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 TD089702 4,4’-二苯基甲烷二异氰酸酯 25g 200元 2011/04/16 D0897 4,4'-二异氰酸二苯甲烷酯 Methylenediphenyl 4,4'-Diisocyanate 500G 425元 2011/04/16 D0897 4,4'-二异氰酸二苯甲烷酯 Methylenediphenyl 4,4'-Diisocyanate 25G 186元
  • 上游原料:氢氧化钠 --> 硝酸 --> 氯 --> 甲醛 --> 氨基苯 --> 一氧化碳
  • Alfa Aesar:4,4'-二异氰酸酯二苯甲烷,98%,stab.with450ppmBHTand450ppmtriphenylphosphite 4,4'-Methylenebis(phenyl isocyanate), 98%, stab. with 450ppm BHT and 450ppm triphenyl phosphite(101-68-8)
  • MOL 文件:101-68-8.mol
  • 海关编码:29291090
  • Hazard Note:Toxic/Corrosive/Lachrymatory/Moisture Sensitive
  • 用途一:用于生产聚氨酯弹性体，制造合成纤维、人造革、无溶剂涂料等
  • Acros Organics:4,4'-二苯基甲烷二异氰酸酯 Methylene di-p-phenyl diisocyanate, stabilized flakes (polymerizes easily), 99.50%(101-68-8)
  • TCI Shanghai:二苯甲烷-4,4'-二异氰酸酯 Methylenediphenyl 4,4'-Diisocyanate,>;97.0%(T)(101-68-8)
  • 职业标准:TWA 0.05 毫克/立方米; STEL 0.2 毫克/立方米
  • 凝固点:37℃
  • 灭火剂:干粉、二氧化碳
  • 可燃性危险特性:明火可燃; 聚合时能释出有毒氮氧化物烟雾
  • 敏感性:Moisture Sensitive/Lachrymatory
  • Sigma Aldrich:101-68-8(sigmaaldrich)
  • MSDS 信息:二苯甲撑二异氰酸酯(101-68-8).msds
  • 刺激数据:眼睛-兔子 100 毫克 中度
  • 储运特性:库房通风低温干燥; 与含水物品、醇类、胺类分开储运

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Isocyanates - Nitrogen Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Volatiles/ Semivolatiles - Environmental Standards
  6. Alpha Sort - Volatiles/ Semivolatiles
  7. M - Alpha Sort
  1. Materials Science 材料科学
  2. Products for Polymer Science Research
  3. Monomers - Polymer Science
  4. Isocyanate Monomers - Monomers
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Monomers
  4. Epoxide Monomers
  1. Functional Group 官能团索引
  2. isocyanate

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