4-Hydroxy-N'-(4-Isopropylbenzylidene)Benzohydrazide (E)-4-羟基-N’-(4-异丙基亚苄基)苯并酰肼

CAS 101574-65-6 MFCD00567155

化学结构图

101574-65-6
SMILES: CC(C)C1C=CC(/C=N/NC(=O)C2C=CC(O)=CC=2)=CC=1

化学属性

Mol. FormulaC17H18N2O2
Mol. Weight282.34

别名和识别编码

Chemical Name4-Hydroxy-N'-(4-Isopropylbenzylidene)Benzohydrazide
Synonym 2-[[4-(1-Methylethyl)phenyl]methylene]hydrazide 4-hydroxybenzoic acid GSK 4716
MDL NumberMFCD00567155
CAS Number101574-65-6
PubChem Substance ID329799950
Chemical Name Translation(E)-4-羟基-N’-(4-异丙基亚苄基)苯并酰肼
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分类

  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Estrogen, G, GlaxoSmithKline, Hormones, Steroid Hormones
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Estrogen, Fluorination Ready Pharma-Developed Compou
  • Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Estrogen, G, GlaxoSmithKline, Hormones, Steroid Hormones

相关文献及参考

  • Ariazi, E.A., et al., Estrogen-related receptors as emerging targets in cancer and metabolic disorders. Curr. Top. Med. Chem 6 , 203-15, (2006) 摘要
  • Wang, S.C., et al., An ERRbeta/gamma agonist modulates GRalpha expression, and glucocorticoid responsive gene expression in skeletal muscle cells. Mol. Cell. Endocrinol. , (2009)
  • Zuercher, W.J., et al., Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. J. Med. Chem. 48 , 3107-9, (2005) 摘要

安全信息

GHS Symbol
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Signal word Warning
Hazard statements
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
WGK Germany3
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Hazard Codes Xi,N
Risk Statements
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R50/53

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Estrogen - Steroid Hormones

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