4-(5,6,7,8-Tetrahydroimidazo[1,5-A]Pyridin-5-Yl)Benzonitrile Hydrochloride 4-(5,6,7,8-四氢咪唑并[1,5-a]吡啶-5-基)苯腈盐酸盐

CAS 102676-31-3 MFCD00866239

化学结构图

102676-31-3
SMILES: Cl.N#CC1C=CC(=CC=1)C1CCCC2=CN=CN21

化学属性

Mol. FormulaC14H13N3·HCl
Mol. Weight259.73

别名和识别编码

Chemical Name4-(5,6,7,8-Tetrahydroimidazo[1,5-A]Pyridin-5-Yl)Benzonitrile Hydrochloride
Synonym 4-(5,6,7,8-Tetrahydroimidazo(1,5-a)pyridin-5-yl)benzonitrile 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)-benzonitrile 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)-benzonitrile Afema CGS 16949A Afema CGS 16949A
MDL NumberMFCD00866239
CAS Number102676-31-3
Alfabeta NameTETRAHYDROIMIDAZOPYRIDINYLBENZONITRILEHYDROCHLORIDE A45678155[]()-----,,,,
PubChem Substance ID329799706
Chemical Name Translation4-(5,6,7,8-四氢咪唑并[1,5-a]吡啶-5-基)苯腈盐酸盐
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分类

  • Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Novartis, Other Steroid Products, Steroid Hormones
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Diversification Ready Pharma-Developed Compounds, F, Hormones, Novartis, Other Steroid Products, Steroid Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

相关文献及参考

  • Van Meeuwen, J., et al., Aromatase inhibition by synthetic lactones and flavonoids in human placental microsomes and breast fibroblasts--a comparative study. Toxicol. Appl. Pharmacol. 228 , 269-276, (2008) 摘要
  • Minnaard-Huiban, M., et al., Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone. Endocrinology 149 , 28-31, (2008)
  • Mikolajczyk, T., et al., The effect of aromatase inhibitor, fadrozole, on sGnRHa stimulated LH secretion in goldfish ( Carassius auratus ) and common carp ( Cyprinus carpio ). Reprod. Biol. 6 , 195-199, (2006)
  • Merck 14 ,3927

安全信息

GHS Symbol
WGK Germany2
Precautionary statements
  • P301+P310
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
Signal word Danger
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H301 Toxic if swallowed 吞食有毒
RTECSDI4952500
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Warnings IRRITANT 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,740,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 63600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,740,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 per

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,740,1995

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,740,1

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2500 ug/kg
SEX/DURATION            : female 16-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   NISFAY Nippon Sanka Fujinka Gakkai Zasshi.  Journal of the Japan Society of
   Obstetrics and Gynecology.  (Nippon Sanka Fujinka Gakkai Zasshi, Hoken
   Kaikan Bekkan, 1-1 Sadohara-cho, Ichigaya, Shijuku-ku, Tokyo 162, Japan)
   V.1-    1949-  Volume(issue)/page/year: 46,227,1994

Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Hazard Codes Xn
Risk Statements
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R22 Harmful if swallowed 吞咽有害

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Other Steroid Products - Steroid Hormones

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