CH5164840

CAS 1052645-73-4 MFCD152645734

化学结构图

1052645-73-4
SMILES: Cc1cc(C)c2cc1C(=O)NCCCNC(=O)CCSc1cc-2nc(N)n1

化学属性

Mol. Weight385.48322
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameCH5164840
FormulaC19H23N5O2S
Synonym CH5164840; CH-5164840; CH 5164840.
IUPAC Name7 -​Thia-​3,​5,​11,​15-​tetraazatricyclo[15.​3.1.12,​6]​docosa-​1(21)​,​2,​4,​6(22)​,​17,​19-​hexaene-​10,​16-​dione, 4-​amino-​18,​20-​dimethyl-.
InChIKeyOMFBVBRFVYLRQT-UHFFFAOYSA-N
InChIInChI=1S/C19H23N5O2S/c1-11-8-12(2)14-9-13(11)15-10-17(24-19(20)23-15)27-7-4-16(25)21-5-3-6-22-18(14)26/h8-10H,3-7H2,1-2H3,(H,21,25)(H,22,26)(H2,20,23,24)
Canonical SMILESNC1=NC(C(C=C2C(NCCCN3)=O)=C(C)C=C2C)=CC(SCCC3=O)=N1
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产品应用

  • CH5164840 is a potent and selective HSP90 inhibitor. CH5164840 showed remarkable antitumor activity against NSCLC cell lines and xenograft models. CH5164840 has potent antitumor activity and is highly effective in combination with erlotinib against NSCLC tumors with EGFR overexpression and mutations.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. EGFR
  1. Medical Research Areas
  2. GPCR & G Protein
  3. EGFR

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