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• 试剂商城
• 直接询价

分类

• Building Blocks, C1 to C5, Chemical Synthesis, Cyanides/Nitriles, Nitrogen Compounds, Organic Building Blocks
• {uni_hamburg} no charge; alcohol; 1fragment
• {SNA} Building Blocks, C1 to C5, Chemical Synthesis, Cyanides/Nitriles, Nitrogen Compounds, Organic Building Blocks
• {SA} Building Blocks, C1 to C5, Chemical Synthesis, Cyanides/Nitriles, Nitrogen Compounds, Organic Building Blocks

产品应用

• 用作纤维素酯类及许多无机盐的溶剂，经加氢可得3-氨基丙醇，用于药物环磷酰胺、心得安等的合成。

相关文献及参考

• Short: II/19b
• Protection of carboxylic acids as 2-cyanoethyl esters can be accomplished by DCC-DMAP coupling. The esters can be cleaved with TBAF in DMF-THF: Chem. Pharm. Bull., 42, 147 (1994), or Na2S in methanol: Chem. Pharm. Bull., 42, 1579 (1994).
• Merck:14,3794
• Merck:14,3794 Beilstein: 3,IV,708
• Can also be used to protect the phosphate group, by condensation with 2,4,6-Triisopropyl­benzenesulfonyl­ chloride, A11458: Chem. Pharm. Bull., 25, 2844 (1977), or DCC: J. Am. Chem. Soc., 83, 159 (1961). Cleavage can be effected with an amine: Tetrahedron Lett., 23, 5119 (1982), ammonia: J. Org. Chem., 59, 2482 (1994); Tetrahedron Lett., 35, 4311 (1994), or TBAF: Tetrahedron Lett., 1255 (1976).
• Precursor of 2-cyanoethyl 2,2,2-trichloroethyl phosphorochloridate, a reagent for the phosphorylation of nucleosides: Synthesis, 831 (1980); see 2,2,2-Trichloroethanol, L08163.

安全信息

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 8,371,1953

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 8,371,1953

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
   G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
   Vol. 3 originally pub. in 1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
   G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
   Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
   Volume(issue)/page/year: 2C,4875,1982

{hazard

其他信息

• 易溶于水、醇、丙酮，微溶于醚，不溶于苯，四氯化碳。
• 上游原料:氰化钠 --> 2-氯乙醇
• 图谱信息:3-羟基丙腈(109-78-4)核磁图( 13 CNMR) 3-羟基丙腈(109-78-4)核磁图( 1 HNMR) 3-羟基丙腈(109-78-4)红外图谱(IR1) 3-羟基丙腈(109-78-4)质谱(MS)
• 毒性分级:中毒
• 急性毒性:口服- 大鼠 LD50:3200 毫克/ 公斤; 口服- 大鼠 LD50:1800 毫克/ 公斤
• 3-羟基丙腈价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 K5627001 3-羟基丙腈puriss》99.0％ 100ml 256元 2011/04/16 C1285 乙撑氰醇 Ethylene Cyanohydrin 25ML 131元 2011/04/16 C1285 乙撑氰醇 Ethylene Cyanohydrin 500ML 655元
• Hazard Note:Irritant
• 类别:有毒物品
• Sigma Aldrich:109-78-4(sigmaaldrich)
• 下游产品:卡波姆树脂 --> 丙烯酸正丁酯 --> 丙烯酸乙酯 --> 3-溴丙酸 --> 3-羟丙酸 --> 活性蓝74 --> N-甲基二乙醇胺 --> 直接黄86
• 蒸气密度:2.5 (vs air)
• 海关编码:29269095
• 蒸气压:<;0.1 mm Hg ( 20 °C)
• Acros Organics:3-羟基丙腈 3-Hydroxypropionitrile, 98%(109-78-4)
• MOL 文件:109-78-4.mol
• Alfa Aesar:3-羟基丙腈,98% 3-Hydroxypropionitrile, 98%(109-78-4)
• 外观性质:无色至淡黄色液体。
• 刺激数据:皮肤- 兔子 500 毫克 轻度; 眼- 兔子 500 毫克 中度
• 灭火剂:干粉、干石粉、二氧化碳、干砂。禁用酸碱灭火剂。
• TCI Shanghai:3-羟基丙腈 Ethylene Cyanohydrin,>;98.0%(GC)(109-78-4)
• 职业标准:STEL 100 毫克/ 立方米
• 用途二:用作纤维素酯类及许多无机盐的溶剂，经加氢可得3-氨基丙醇，用于药物环磷酰胺、心得安等的合成。
• 方法一:由丙烯腈水合而得。另一种制法是由2-氯乙醇与氰化钠反应制得。
• 可燃性危险特性:明火可燃; 受热或接触酸放出有毒氰化物和氮氧化物气体
• 用途一:用作医药、有机合成中间体
• F:8-10
• MSDS 信息:3-羟基丙腈(109-78-4).msds
• 储运特性:库房通风低温干燥; 与氧化剂、强酸类、强碱类、食品添加剂分开存放