Chlorprothixene 氯普噻吨

CAS 113-59-7 MFCD00869180

化学结构图

113-59-7
SMILES: CN(C)CCC=C1c2ccccc2Sc2ccc(Cl)cc21

化学属性

Mol. FormulaC18H18ClNS
Mol. Weight316
SolubilityDMSO 6 mg/mL Water <1 mg/mL Ethanol 28 mg/mL
Melting Point95.0 to 99.0 deg-C

别名和识别编码

Chemical NameChlorprothixene
Synonym (Z)-2-Chloro-9-(omega-dimethylaminopropylidene)thioxanthene (Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-1-propanamine 1-Propanamine, 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-, (Z)- 1-propanamine, 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-,(Z)- 3-(2-Chlorothioxanthen-9-ylidene)-N,N-dimethyl-propan-1-amine 9H-thioxanthene, 1-propanamine deriv. cis-chlorprothixene CPT CPX Chlorprothixen Chlorprothixene Chlorprotixen Chlorprotixene Chlothixen Iaractan MK 184 N 714 Paxyl Rentovet Ro 4-0403 Tactaran Taractan Tarasan Traquilan Trictal Truxal Truxaletten Truxil {} {} {}
EC Number204-032-8
CAS Number113-59-7
Chemical Name Translation氯普噻吨
Wiswesser Line NotationT C666 BS IYJ FG IU3N1&1
LabNetwork Molecule IDLN01342302
Reaxys-RN9208755
Merck Number2188
PubChem Substance ID667467
MDL NumberMFCD00869180
InChIInChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3/b14-7-
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {uni_hamburg} no charge; sulfur heterocycle; carbocycle; aromatic; large ring; fused rings; 6ring; 10ring; 14ring; sulfide; 1fragment

相关文献及参考

  • Short: IV/8A Title: Enthalpies of Fusion and Transition of Organic Compounds Author: Zhang, Z.-Y.; Frenkel, M.; March, K.N.; Wilhoit, R.C. Editor: Marsh, K.N. Source: Landolt-Börnstein, New Series Volume: IV/8A Year: 1995 Keyword: organic compounds; enthaly of fusion; melting point; phase transition ISBN: 3-540-58854-X ISBN: 978-3-540-58854-2 Internet Resource: DOI:10.1007/b55145 RefComment: VIII, 588 pages.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

Storage condition 储存温度-20°C 0-10°C
RTECSXO1050000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56200 ug/kg
TOXIC EFFECTS

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50100 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   47,5944,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 182 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,33,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,252,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 36 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,373,1990

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE                    : 360 mg/kg
SEX/DURATION            : male 15 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - impotence
REFERENCE :
   AJPSAO American Journal of Psychiatry.  (American Psychiatric Assoc.,
   Circulation Dept., 1400 K St., NW, Washington, DC 20005)  V.78-    1921-
   Volume(issue)/page/year: 120,1004,1964

Hazard Class6.1
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
UN Number 2811
Signal word
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P310
  • P301+P310+P330
  • P301+P316
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
GHS Symbol
Packing GroupIII

其他信息

  • Chlorprothixene与多巴胺和组织胺受体（如D1， D2， D3， D5， H1， 5-HT2， 5-HT6和5-HT7）具有强结合力， Ki值分别为18nM， 2.96 nM， 4.56 nM， 9 nM， 3.75 nM， 9.4 nM， 3 nM和5.6 nM。

系列性分类

相关产品推荐