Propoxur 残杀威

CAS 114-26-1 MFCD00055455

化学结构图

114-26-1
SMILES: CNC(=O)Oc1ccccc1OC(C)C

化学属性

Mol. FormulaC11H15NO3
Mol. Weight209.27
Melting Point84-87°C
Solubility微溶于水，溶于多数有机溶剂。
Flash Point-18 °C
Density1.0

别名和识别编码

Chemical NamePropoxur
CAS Number114-26-1
Synonym ######## 2-(1-Methylethoxy)phenol methylcarbamate 2-(1-Methylethoxy)phenyl N-methylcarbamate 2-(1-Methylethoxy)phenyl methylcarbamate 2-(1-methylethoxy)phenyl methylcarbamate 2-(1-methylethoxy)phenylmethylcarb 2-(1-甲基乙氧基)苯基氨基甲酸甲酯 2-ISO-PROPOXYPHENYL METHYLCARBAMATE 2-ISOPROPO 2-Isopropoxyphenyl N-methylcarbamate 2-Isopropoxyphenyl-N-methylcarbamat 2-Isopropoxyphenylmethylcarbamat 2-isopropoxyphenyl methyl carbamate 2-isopropoxyphenyl methylcarbamate 2-isopropyloxyphenyl N-methylcarba 2-异丙氧基苯基-N-甲基氨基甲酸酯 APROCARB(R) Aprocarb Arprocarb B BAY 5122 BAY 9010 BAYER 39007 BAYGON (TM) Bayer 39007 Baygon Blat
PubChem Substance ID4944
EC Number204-043-8
Beilstein Registry Number1879891
MDL NumberMFCD00055455
Chemical Name Translation残杀威
Merck Number13,7929
Wiswesser Line Notation1Y1&OR BOVM1
LabNetwork Molecule IDLN01307728
InChIInChI=1S/C11H15NO3/c1-8(2)14-9-6-4-5-7-10(9)15-11(13)12-3/h4-8H,1-3H3,(H,12,13)
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分类

  • A-B, Acaricides, Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, B, BA - BH, Carbamates, Chromatography, Environmental Standards, Insecticides, Pesticides, Pesticides & Metabolites
  • {SNA} Acaricides,
  • {SNA} Acaricides, All alphabetically sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Carbamates, Chromatography, Environmental Standards, Insecticides, N-P, P, PON - PT,
  • {Chemicalbook} 农药: 杀虫（螨）剂: 有机氮杀虫剂

产品应用

  • 非内吸性杀虫剂。具有触杀、胃毒和熏蒸作用，击倒快，速成度接近敌敌畏，持效期长。能杀体外寄生虫、家庭卫生害虫（蚊、蝇、蟑螂等）和仓贮害虫。

相关文献及参考

  • Merck:13,7929
  • Voss, G.: Anzeig. Schaedling., 40, 73 (1967); Fraser, J. et al.: J. Sci. Food. Agric., 8 (1968); Corbel, V. et al.: Neurotoxicology, 27, 508 (2006);
  • Short: IV/8A
  • Short: EINECS

安全信息

GHS Symbol
WGK Germany3
Hazard Codes T,N T;N T;N,N,T,Xn,F
Hazard statements
  • H300 Fatal if swallowed 吞食致命
  • H301 Toxic if swallowed 吞食有毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H331 Toxic if inhaled 吸入中毒
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSFC3150000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P310
  • P302+P352
  • P302+P352+P312
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P307+P311
  • P308+P313
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P337+P313
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S37 Wear suitable gloves 戴适当手套；
  • S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐：立即求医并出示该容器或标签；
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R26 Very toxic by inhalation 吸入极毒
  • R21 Harmful in contact with skin 与皮肤接触有害
  • R50/53
  • R11 Highly flammable 非常易燃
  • R38 Irritating to skin 刺激皮肤
  • R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
  • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
UN Number 2811/2588 UN 2811/2588
Storage condition 2-8°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 46500 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   7,606,1965

{h

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1440 mg/m3/1H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer
   Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R.,
   Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971  Volume(issue)/page/year:
   -,70,1971

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 24 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Cardiac - pulse rate
   Blood - change in clotting factors
REFERENCE :
   PGMJAO Postgraduate Medical Journal.  (Blackwell Scientific Pub. Ltd., POB
   88, Oxford, UK) V.1-    1925-  Volume(issue)/page/year: 63,311,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJIMAG British Journal of Industrial Medicine.  (British Medical Journal,
   Box 560B, Kennebunkport, ME 04046)  V.1-    1944-  Volume(issue)/page/year:
   22,317,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSUR

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - hamster
DOSE/DURATION           : 250 mg/kg
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   58,152,1986

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 232,45,1990

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 232,45,1990

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 250 ng/plate
REFERENCE :
   RPZHAW Roczniki Panstwowego Zakladu Higieny.  (Ars Polona, POB 1001, 00-068
   Warsaw 1, Poland) V.1-    1950-  Volume(issue)/page/year: 30,81,1979

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 5 ppm
REFERENCE :
   RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione
   Umana.  Review of Science and Technology of Food and Human Nutrition.
   (Bologna, Italy)  V.5-6, 1975-76.  Discontinued.  Volume(issue)/page/year:
   6,161,1976

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 125 mg/kg/5D (Continuous)
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, s

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1600 mg/kg
SEX/DURATION            : female 6-22 day(s) after conception
                          lactating female 15 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - behavioral
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 20,624,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 650 mg/kg
SEX/DURATION            : female 7-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food
   Contaminants, and Agricultural Wastes.  (Marcel Dekker, 270 Madison Ave.,
   New York, NY 10016)  V.B11-

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 600 mg/kg
SEX/DURATION            : female 7-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food
   Contaminants, and Agricultural Wastes.  (Marcel Dekker, 270 Madison Ave.,
   New York, NY 10016)  V.B11-    1976-  Volume(issue)/page/year: 20,373,1985

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其他信息

  • RTECS号:FC3150000
  • 毒害物质数据:114-26-1(Hazardous Substances Data)
  • EPA化学物质信息:Phenol, 2-(1-methylethoxy)-, methylcarbamate(114-26-1)
  • 图谱信息:残杀威(114-26-1)红外图谱(IR1) 残杀威(114-26-1)核磁图( 13 CNMR) 残杀威(114-26-1)核磁图( 1 HNMR) 残杀威(114-26-1)质谱(MS) 残杀威(114-26-1)红外图谱(IR2)
  • 生产方法:异氰酸甲酯法 邻异丙氧基苯酚的制备 将1mol 2-溴丙烷慢慢滴入正在回流的1mol邻苯二酚、2mol碳酸钾、丁酮和相转移催化剂的混合液中，滴毕继续回流反应一定时间，然后蒸出绝大部分丁酮，加入足量的水溶解固体盐，再以苯萃取，萃取液用稀氢氧化钠溶液萃取，萃取液用稀盐酸中和后，再用苯萃取，氯化钙干燥，蒸出大部分苯，减压收集84～86℃/333.3Pa的馏分。得无色透时邻异丙氧基苯酚，n 25 D 1.5131，产率>;60%。 异氰酸甲酯的制备 见甲萘威的制备方法。 残杀威的合成 将1mol邻异丙氧基苯酚溶于二噁烷中。加入1mol缚酸剂，在搅拌下分次加入1mol的固体甲氨基甲酰氯，室温搅拌1h，然后将混合液倾入冰水中，充分搅拌，结晶完全后抽滤，并用冷水、石油醚洗涤，干燥后得残杀威，产率75%，熔点90.5～91℃。 国外文献报道，残杀威多采用异氰酸酯法生产，即将邻异丙氧基苯酚与异氰甲酯在二噁烷溶剂中，加数滴三乙胺作催化剂反应制得。经洗涤、干燥、重结晶后制得残杀威，收率84%。 氯甲酸酯法 先合成异丙氧基氯甲酸酚酯，再胺解合成残杀威。两步反应均在低温下进行。
  • NIST化学物质信息:2-Isopropoxyphenyl N-methylcarbamate(114-26-1)
  • 用途:速效、长残效氨基甲酸酯类杀虫剂，具有触杀、胃毒和熏蒸作用，无内吸作用。主要用于防治水稻螟虫、稻叶蝉、稻飞虱、棉蚜、果树介壳虫、锈壁虱、杂粮害虫和卫生害虫。用药量3～7.5g有效成分/100m 2 ，一般使用含量为0.03%～0.075%。例如防治水稻叶蝉、稻飞虱，用2%～3%粉剂225～338g/100m 2 喷粉，或以0.05%～0.1%含量的乳剂喷雾，或用4%颗粒剂300～338g进行防治。防治水稻螟虫，用15%乳油稀释400倍液喷雾。
  • 20℃水中溶解度约0.2%，溶于大多数有机溶剂。在强碱性介质中不稳定。
  • 外观性质:白色结晶粉末，稍带特殊气味。
  • 毒性:雄性大鼠急性经口LD 50 为90～128mg/kg，雌性为104mg/kg，雄性小鼠为100～109mg/kg。大鼠急性经皮LD 50 为800～1000mg/kg。大鼠2年饲喂试验无作用剂量为800～1000mg/kg饲料。鲤鱼LC 50 >10mg/L。燕八哥急性经口LD 50 为15～30mg/kg。对蜜蜂高毒。
  • PackingGroup:III
  • HazardClass:6.1(b)
  • MOL 文件:114-26-1.mol

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Pesticides & Metabolites - Environmental Standards
  6. Pesticides - Pesticides & Metabolites
  7. Acaricides - Pesticides
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Pesticides & Metabolites - Environmental Standards
  6. Alpha sort - Pesticides & Metabolites
  7. N-P - Alpha sort
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. B - Alphabetic
  5. BA - BH - B

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