1-Acetyl-2-Phenylhydrazine N-乙酰苯肼

CAS 114-83-0 MFCD00008672

化学结构图

114-83-0
SMILES: CC(=O)NNc1ccccc1

化学属性

Mol. FormulaC8H10N2O
Mol. Weight150.18
Melting Point128-131°C
TSCAYes
Density1.143
Solubility溶于热水、醇，微溶于醚。
Stability对光敏感
Boiling Point214.1ºC at 760 mmHg

别名和识别编码

Chemical Name1-Acetyl-2-Phenylhydrazine
MDL NumberMFCD00008672
CAS Number114-83-0
PubChem Substance ID8247
EC Number204-055-3
Synonym N'-Phenylacetohydrazide {LY} N'-Phenylacetohydrazide {} {LY} N'-Phenylacetohydrazide {} {} {LY} N'-Phenylacetohydrazide {} {} {} {LY} N'-Phenylacetohydrazide {} {} {} {} {LY} N'-Phenylacetohydrazide {} {} {} {} {} {LY} N'-Phenylacetohydrazide {} {} {} {} {} {} {LY} N'-Phenylacetohydrazide {} {} {} {} {} {} {} {LY} N'-Phenylacetohydrazide {} {} {} {} {} {} {} {} {LY} N'-Phenylacetohydrazide {} {} {} {} {} {} {} {} {} {LY} N'-Phenylacetohydrazide {} {} {} {} {} {} {} {} {} {} {LY} N'-Phenylacetohydrazide {} {} {} {} {} {} {} {} {} {} {} {LY} N'-Phenylacetohydrazide {} {} {} {} {} {} {} {} {} {} {} {} {LY} N'-Phenylacetohydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N'-Phenylacetohydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N'-Phenylacetohydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N'-Phenylacetohydrazide {} {} {} {} {} {} {} {} {} {} {} {} {}
Beilstein Registry Number742880
Chemical Name TranslationN-乙酰苯肼
Reaxys-RN742880
Wiswesser Line Notation1VMMR
LabNetwork Molecule IDLN00238551
InChIInChI=1S/C8H10N2O/c1-7(11)9-10-8-5-3-2-4-6-8/h2-6,10H,1H3,(H,9,11)
Canonical SMILESCC(NNC1=CC=CC=C1)=O
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分类

  • {SNA} Carcinogens, Cell Biology, 癌症研究
  • {SNA} Cancer Research, Carcinogens, Cell Biology
  • {SNA} Cancer Research, Carcinogens
  • {SNA} Carcinogens, 癌症研究, 细胞生物学
  • {SNA} 癌症研究, 细胞生物学, 致癌物

产品应用

  • 有机合成。稳定剂。

相关文献及参考

  • Beilstein:15(2)92

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P305+P351+P338
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSAJ2900000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Packing GroupIII
UN Number 2811 UN 2811 6.1/PG 3
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Hazard Codes 6.1 Xn
Storage condition 2-8°C {LY} 2-8°C Store at room temperature {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°
Hazard Class6.1 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 31 gm/kg/79W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Vascular - tumors
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   39,584,1979

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD691-490

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 270 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 14,162,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 333 ug/plate
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11(Suppl 12),1,1988

其他信息

  • MOL 文件:114-83-0.mol
  • Alfa Aesar:N-乙酰-N‘-苯肼,98% N-Acetyl-N'-phenylhydrazine, 98%(114-83-0)
  • 储运特性:库房通风低温干燥
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • 毒性分级:高毒
  • 类别:有毒物品
  • 方法一:由苯肼和乙酸反应。将苯肼，乙酸，水加热6h，趁热倒出，冷至0℃以下，过滤得粗品，用水重结晶，80℃干燥而得。
  • 用途一:用于制药及有机合成工业
  • TCI Shanghai:乙酰苯肼 1-Acetyl-2-phenylhydrazine,>;98.0%(N)(114-83-0)
  • 用途三:有机合成。稳定剂。
  • 1-乙酰基-2-苯基肼价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30003226 N-乙酰苯肼;乙酰基苯联氨 100g 51.9元 2011/08/23 30003260 N-乙酰苯肼;乙酰基苯联氨 100g 50元 2011/04/16 A0107 1-乙酰-2-苯肼 1-Acetyl-2-phenylhydrazine 25G 349元
  • 急性毒性:口服-小鼠 LD50: 270 毫克/公斤; 腹腔-小鼠 LDL0: 150 毫克/公斤
  • 用途二:有机中间体。稳定剂。
  • Sigma Aldrich:114-83-0(sigmaaldrich)
  • MSDS 信息:乙酰苯肼(114-83-0).msds
  • 海关编码:29280090
  • 易溶于乙醇，微溶于乙醚、冷水。热水中溶解度稍大些
  • 图谱信息:1-乙酰基-2-苯基肼(114-83-0)核磁图( 1 HNMR) 1-乙酰基-2-苯基肼(114-83-0)质谱(MS) 1-乙酰基-2-苯基肼(114-83-0)核磁图( 13 CNMR) 1-乙酰基-2-苯基肼(114-83-0)Raman光谱 1-乙酰基-2-苯基肼(114-83-0)红外图谱(IR1) 1-乙酰基-2-苯基肼(114-83-0)红外图谱(IR2)
  • Acros Organics:N-乙酰苯肼 1-Acetyl-2-phenylhydrazine, 98%(114-83-0)
  • 外观性质:灰白色粉末。
  • 可燃性危险特性:可燃; 加热分解释放有毒氮氧化物烟雾

系列性分类

  1. Life Science 生命科学
  2. Cancer Research
  3. Carcinogens - Cancer Research

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