Molidustat Bay85-3934 消毒剂BAY-85-934

CAS 1154028-82-6 MFCD254028826

化学结构图

1154028-82-6
SMILES: O=c1c(-n2ccnn2)c[nH]n1-c1cc(N2CCOCC2)ncn1

化学属性

Mol. Weight314.3
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name Translation消毒剂BAY-85-934
Chemical NameMolidustat Bay85-3934
FormulaC13H14N8O2
Synonym BAY 85-3934; BAY-85-3934; BAY85-3934; BAY 853934; BAY-853934; BAY853934; Molidustat.
IUPAC Name2-(6-morpholinopyrimidin-4-yl)-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-3(2H)-one
InChIKeyIJMBOKOTALXLKS-UHFFFAOYSA-N
InChIInChI=1S/C13H14N8O2/c22-13-10(20-2-1-16-18-20)8-17-21(13)12-7-11(14-9-15-12)19-3-5-23-6-4-19/h1-2,7-9,17H,3-6H2
Canonical SMILESO=C1N(C2=NC=NC(N3CCOCC3)=C2)NC=C1N4N=NC=C4
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产品应用

  • Molidustat, also known as BAY 85-3934, is a novel inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH) which stimulates erythropoietin (EPO) production and the formation of red blood cells. Phase I data have shown that inhibition of HIF-PH by Molidustat results in an increase in endogenous production of EPO. Molidustat is currently clinical trials at Bayer for the treatment of patients suffering from renal anemia due to chronic kidney disease.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. HIF
  1. Medical Research Areas
  2. Epigenetics
  3. HIF

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