Fumonisin B2 伏马菌素B2, 来源于串珠镰刀菌

CAS 116355-84-1 MFCD00133350

化学结构图

116355-84-1
SMILES: CCCC(C)CC(OC(=O)CC(CC(O)=O)C(O)=O)C(CC(C)CCCCCCC(O)CC(O)C(C)N)OC(=O)CC(CC(O)=O)C(O)=O

化学属性

Mol. FormulaC34H59NO14
Mol. Weight705.83

别名和识别编码

Chemical NameFumonisin B2 from Fusarium moniliforme
CAS Number116355-84-1
Synonym (2R,2'R)-1,2,3-Propanetricarboxylic Acid 1,1'-[(1S,2R)-1-[(2S,9R,11S,12S)-12-Amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl] Ester Fumonisin B2
MDL NumberMFCD00133350
PubChem Substance ID24894857
Chemical Name Translation伏马菌素B2, 来源于串珠镰刀菌
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分类

  • {SA} Biochemicals and Reagents, Core Bioreagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, R to Z, Research Essentials, Sphingosine acyltransferase
  • Chiral Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Amines
  • {SNA} Core Bioreagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, R to Z, Research Essentials, Sphingosine acyltransferase, 生化试剂, 酶、抑制剂和底物

产品应用

  • A mycotoxin produced by mold associated with corn. Inhibitor of sphingosine N-acyltransferase. Blocks the formation of ceramide from sphingosine.

相关文献及参考

  • [2]. Shephard GS, et al. Disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin-containing Fusarium moniliforme culture material. Toxicon. 1996 May;34(5):527-34.
  • [3]. Wei T, et al. Natural occurrence of fumonisins B1 and B2 in corn in four provinces of China. Food Addit Contam Part B Surveill. 2013;6(4):270-4.
  • 1. Marasas, W.F., et al., Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize J. Nutr. 134 , 711-716, (2004)
  • 2. Morgensen, J.M., et al., Production of Fumonisin B 2 and B 4 by Aspergillus niger on grapes and raisins J. Agric. Food Chem. 58 , 954-958, (2010) 摘要
  • Klosowski, G., et al.: Biores. Technol., 101, 9723 (2010),
  • Merrill, A.H., and Wang, E., Enzymes of ceramide biosynthesis Meth. Enzymol. 209 , 427-437, (1992

安全信息

RTECSTZ8335000
WGK Germany3
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P302+P350
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Signal word
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H330 Fatal if inhaled 吸入致命
  • H310 Fatal in contact with skin 皮肤接触致命
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H351 Suspected of causing cancer 怀疑致癌
  • H300 Fatal if swallowed 吞食致命
  • H319 Causes serious eye irritation 严重刺激眼睛
Hazard Codes T+
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S22 Do not breathe dust 不要吸入粉尘；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
UN Number
Packing GroupI

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. R to Z - Enzyme Inhibitors by Enzyme
  7. Sphingosine acyltransferase - R to Z
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Dry Powder Media
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Spermine synthase
  1. Medical Research Areas
  2. Metabolism
  3. Acyltransferase  (酰基转移酶)

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