CCT196969

CAS 1163719-56-9 MFCD263719569

化学结构图

1163719-56-9
SMILES: CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)n(-c2ccccc2)n1

化学属性

Mol. Weight513.52
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name Translation
Chemical NameCCT196969
FormulaC27H24FN7O3
Synonym CCT196969; CCT-196969; CCT 196969.
IUPAC Name1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea
InChIKeyKYYKGSDLXXKQCR-UHFFFAOYSA-N
InChIInChI=1S/C27H24FN7O3/c1-27(2,3)21-14-22(35(34-21)16-7-5-4-6-8-16)32-26(37)31-19-10-9-17(13-18(19)28)38-20-11-12-29-25-24(20)30-15-23(36)33-25/h4-15H,1-3H3,(H,29,33,36)(H2,31,32,37)
Canonical SMILESFC1=CC(OC2=C3C(NC(C=N3)=O)=NC=C2)=CC=C1NC(NC4=CC(C(C)(C)C)=NN4C5=CC=CC=C5)=O
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产品应用

  • CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. CCT196969 blocked growth of BRAF-mutant and NRAS-mutant melanoma cells, inhibiting MEK–ERK, in vitro and in vivo. CCT196969 also prevented growth of xenografts derived from patient tumours with acquired or intrinsic resistance to BRAF and MEK inhibitors. BRAF and MEK inhibitors are effective in BRAF mutant melanoma, but most patients eventually relapse with acquired resistance, and others present intrinsic resistance to these drugs.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. Src
  1. Medical Research Areas
  2. JAK/STAT
  3. ERK
  1. Medical Research Areas
  2. MARK
  3. MEK
  1. Medical Research Areas
  2. MARK
  3. Raf

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