Carbarsone 卡巴胂

CAS 121-59-5 MFCD00025427

化学结构图

121-59-5
SMILES: NC(=O)Nc1ccc([As](=O)(O)O)cc1

化学属性

Mol. FormulaC7H9AsN2O4
Mol. Weight260.10

别名和识别编码

Chemical NameCarbarsone
CAS Number121-59-5
Synonym Amebarsone Arsonic acid, (4-((aminocarbonyl)amino)phenyl)- p-Carbamidobenzenearsonic acid N-Carbamyl arsanilic acid N-Carbamoylarsanilic acid ######## Aminoarson 4-Carbamylaminophenylarsonic acid Histocarb Pentarsone (4-((Aminocarbonyl)amino)phenyl)arsonic acid Kutan Ameban Kyselina N-karbamylarsanilova Fenarsone 4-Ureido-1-phenylarsonic acid Carbarsone Amibiarson p-Arsonophenylurea Benzenearsonic acid, p-ureido- Aminarsone Amabevan p-Carbamino phenyl arsonic acid p-Ureidobenzenearsonic acid Carbaminophenyl-p-arsonic acid Carb-O-Sep Aminarson Leucarsone Arsambide
Chemical Name Translation卡巴胂
Wiswesser Line NotationZVMR D-AS-QQO
Beilstein Registry Number2940926
PubChem Substance ID8480
InChIInChI=1S/C7H9AsN2O4/c9-7(11)10-6-3-1-5(2-4-6)8(12,13)14/h1-4H,(H3,9,10,11)(H2,12,13,14)
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分类

  • Amines
  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Carbarsone is an antiamebic. Carbarsone is used as antihistomonad in turkeys.

相关文献及参考

  • Khalifah, R., et al.: Biochemistry, 16, 2241 (1977),
  • Supuran, C., et al.: Eur. J. Med. Chem., 31, 439 (1996),
  • Supuran, C., et al.: J. Enzyme Inhib., 12, 37 (1997),

安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5000 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   26,619,1966

RTECSCF9275000 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 29,125,1931

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 29,125,1931

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 80,393,1944

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 29,125,1931

TYPE OF TEST            : LD50 - Leth

系列性分类

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