CAS 1225451-84-2 MFCD325451842-SKLB1002 2-((6,7-二甲氧基喹唑啉-4-基)硫基)-5-甲基-1,3,4-噻二唑 -LabNovo

SMILES: COc1cc2ncnc(Sc3nnc(C)s3)c2cc1OC

Chemical Name Translation	2-((6,7-二甲氧基喹唑啉-4-基)硫基)-5-甲基-1,3,4-噻二唑
Chemical Name	SKLB1002
Formula	C13H12N4O2S2
Synonym	SKLB1002; SKLB 1002; SKLB1002.
IUPAC Name	2-((6,7-dimethoxyquinazolin-4-yl)thio)-5-methyl-1,3,4-thiadiazole
InChIKey	RQVGFDBMONQTBC-UHFFFAOYSA-N
InChI	InChI=1S/C13H12N4O2S2/c1-7-16-17-13(20-7)21-12-8-4-10(18-2)11(19-3)5-9(8)14-6-15-12/h4-6H,1-3H3
Canonical SMILES	CC1=NN=C(SC2=C3C=C(OC)C(OC)=CC3=NC=N2)S1

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SKLB1002 is a new potent VEGFR2 inhibitor, which could significantly inhibit HUVEC proliferation, migration, invasion, and tube formation. Western blot analysis was conducted, which indicated that SKLB1002 inhibited VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal-regulated kinase, focal adhesion kinase, and Src. In vivo zebrafish model experiments showed that SKLB1002 remarkably blocked the formation of intersegmental vessels in zebrafish embryos. SKLB1002 inhibits angiogenesis and may be a potential drug candidate in anticancer therapy.

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

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