6-(1H-Indazol-6-Yl)-N-(4-Morpholinophenyl)Imidazo[1,2-a]Pyrazin-8-Amine 6-(1H-吲唑-6-基)-N-[4-(4-吗啉基)苯基]咪唑并[1,2-a]吡嗪-8-胺

CAS 1229208-44-9 MFCD329208449

化学结构图

1229208-44-9
SMILES: c1cn2cc(-c3ccc4cn[nH]c4c3)nc(Nc3ccc(N4CCOCC4)cc3)c2n1

化学属性

Mol. Weight411.46
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name Translation6-(1H-吲唑-6-基)-N-[4-(4-吗啉基)苯基]咪唑并[1,2-a]吡嗪-8-胺
Chemical Name6-(1H-Indazol-6-Yl)-N-(4-Morpholinophenyl)Imidazo[1,2-a]Pyrazin-8-Amine
FormulaC23H21N7O
Synonym Entospletinib; GS9973; GS 9973; GS-9973.
IUPAC Name6-(1H-indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine
InChIKeyXSMSNFMDVXXHGJ-UHFFFAOYSA-N
InChIInChI=1S/C23H21N7O/c1-2-17-14-25-28-20(17)13-16(1)21-15-30-8-7-24-23(30)22(27-21)26-18-3-5-19(6-4-18)29-9-11-31-12-10-29/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)
Canonical SMILESC12=NC=CN1C=C(C3=CC4=C(C=C3)C=NN4)N=C2NC5=CC=C(N6CCOCC6)C=C5
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产品应用

  • Entospletinib, also known as GS-9973, is a highly selective and orally efficacious Syk inhibitor which is currently undergoing clinical evaluation for autoimmune and oncology indications. In Phase II clinical trials, Entospletinib demonstrates clinical activity in subjects with relapsed or refractory CLL with acceptable toxicity.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. Syk

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