1-Hydroxybenzotriazole hydrate, 99% 1-羟基苯并三氮唑 水合物

CAS 123333-53-9 MFCD00065690

化学结构图

123333-53-9
SMILES: O.On1nnc2ccccc21

化学属性

Mol. FormulaC6H7N3O2
Mol. Weight153.14
Melting Point155-158°C
TSCAYes
Density1.51
Boiling Point248.8 °C at 760 mmHg

别名和识别编码

Chemical Name1-Hydroxybenzotriazole hydrate, 99%
CAS Number123333-53-9
Alfabeta NameBENZOTRIAZOLOLHYDRATE H11231----,,
MDL NumberMFCD00065690
Synonym 1H-Benzo[d][1,2,3]triazol-1-ol xhydrate {LY} 1H-Benzo[d][1,2,3]triazol-1-ol xhydrate {} {LY} 1H-Benzo[d][1,2,3]triazol-1-ol xhydrate {} {} {LY} 1H-Benzo[d][1,2,3]triazol-1-ol xhydrate {} {} {} {LY} 1H-Benzo[d][1,2,3]triazol-1-ol xhydrate {} {} {} {} {LY} 1H-Benzo[d][1,2,3]triazol-1-ol xhydrate {} {} {} {} {} {LY} 1H-Benzo[d][1,2,3]triazol-1-ol xhydrate {} {} {} {} {} {} {LY} 1H-Benzo[d][1,2,3]triazol-1-ol xhydrate {} {} {} {} {} {} {} {LY} 1H-Benzo[d][1,2,3]triazol-1-ol xhydrate {} {} {} {} {} {} {} {} {LY} 1H-Benzo[d][1,2,3]triazol-1-ol xhydrate {} {} {} {} {} {} {} {} {} {LY} 1H-Benzo[d][1,2,3]triazol-1-ol xhydrate {} {} {} {} {} {} {} {} {} {} {LY} 1H-Benzo[d][1,2,3]triazol-1-ol xhydrate {} {} {} {} {} {} {} {} {} {} {} {LY} 1H-Benzo[d][1,2,3]triazol-1-ol xhydrate {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1H-Benzo[d][1,2,3]triazol-1-ol xhydrate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1H-Benzo[d][1,2,3]triazol-1-ol xhydr
PubChem Substance ID2796029
Beilstein Registry Number4515
EC Number219-989-7
Chemical Name Translation1-羟基苯并三氮唑 水合物
InChIInChI=1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2
Canonical SMILESON1N=NC2=CC=CC=C21.O
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分类

  • {SNA} Active Esters/Additives, Chemical Synthesis, Coupling, Synthetic Reagents
  • {SNA} Active Esters/Additives, Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling, Synthetic Reagents

产品应用

  • 合成乌苯美司的中间体、多肽保护剂。广泛用于在以碳二亚胺类缩合剂进行的多肽缩合反应,可显著降低消旋比率,亦用于多肽片断缩合时防止消旋的产生。

相关文献及参考

  • Widely used additive which reduces racemization in the carbodiimide method of peptide coupling: Chem. Ber., 103, 788 (1970); J. Am. Chem. Soc., 93, 6318 (1971); Helv. Chim. Acta, 56, 717 (1973). The rate of peptide coupling is increased both in the solution method: Chem. Ber., 3626 (1973), and on solid supports: Tetrahedron Lett., 199 (1976). Addition of CuCl2 further reduces racemization: J. Chem. Soc., Chem. Commun., 419 (1988). A two-phase solvent system (DCM-water or isopropyl acetate-water) in conjunction with 1-(3-Dimethyl­aminopropyl)-3-ethyl­carbodiimide hydrochloride, A10807 (water-soluble carbodiimide), has been found to give superior results in this type of peptide coupling: J. Org. Chem., 60, 3569 (1995). Substoichiometric amounts (ca. 0.1 mol) of the additive in conjunction with the same coupling agent in DMF-water have been found to give good results: Chem. Lett., 1 (1997). The reagent also be used to form active esters with coupling as a separate step. For peptide reagents, see Appendix 6.
  • For use in protection of diols as cyclic silyl ethers, see Di-tert-butyl­dichlorosilane, L03162.

安全信息

Warnings IRRITANT
WGK Germanynwg
GHS Symbol
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P370+P380
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H203 Explosive; fire, blast or projection hazard 爆炸品;火灾、爆炸或喷射危险。
  • H228 Flammable solid 易燃固体
Signal word Danger Warning
RTECSDM1288000
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S37 Wear suitable gloves 戴适当手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S35 This material and its container must be disposed of in a safe way 该物料及其容器必须以安全方式处置;
Risk Statements
  • R1 Explosive when dry 干燥时易爆
  • R11 Highly flammable 非常易燃
  • R44 Risk of explosion if heated under confinement 密封下加热有爆炸危险
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Hazard Codes F
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

系列性分类


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