DL-Aminoglutethimide 氨鲁米特

CAS 125-84-8 MFCD00010122

化学结构图

125-84-8
SMILES: CCC1(c2ccc(N)cc2)CCC(=O)NC1=O

化学属性

Mol. FormulaC₁₃H₁₆N₂O₂
Mol. Weight232.28
Melting Point151-153ºC
SolubilityH2O: 0.2 mg/mL, slightly soluble

别名和识别编码

Chemical NameDL-Aminoglutethimide
CAS Number125-84-8
Synonym (+/-)-P-AMINOGLUTETHIMIDE (RS)-2-ETHYL-2-(4-AMINO-PHENYL)-GLUTARIMIDE (RS)-3-(4-AMINO-PHENYL)-3-ETHYL-PIPERIDINE-2,6-DIONE (RS)-3-ETHYL-3-(4-AMINO-PHENYL)-2,6-DIOXO-PIPERIDINE 2,6-Piperidinedione, 3-(4-aminophenyl)-3-ethyl- 2-(p-Aminophenyl)-2-ethylglutarimide 2-(p-Aminophenyl)-2-ethylglutarimide2,6-piperidinedione, 3-(4-aminophenyl)-3-ethyl- 2-(p-aminophenyl)-2-ethyl-glutarimid 3-(4-AMINOPHENYL)-3-ETHYL-2,6-PIPERIDINEDIONE 3-(4-AMINOPHENYL)-3-ETHYLPIPERIDINE-2,6-DIONE 3-(4-Aminophenyl)-3-ethyl-2,6-Piperidinedione 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione 3-(4-aminophenyl)-3-ethyl-6-piperidinedione 3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione 3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione 3-Ethyl-3-(p-aminophenyl)
PubChem Substance ID2145
EC Number204-756-4
MDL NumberMFCD00010122
Chemical Name Translation氨鲁米特
Merck Number440
Wiswesser Line NotationT6VMVTJ D2 DR DZ
Beilstein Registry Number0210656
LabNetwork Molecule IDLN00222781
InChIInChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)
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分类

  • A to C, A-AM, Antitumor Agents, Approved Therapeutics/Drug Candidates, Aromatase Inhibitors, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cytochrome P450, Cytokines, Growth Factors and Hormones, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Hormones, Novartis, Other Steroid Products, Steroid Hormones, Tumor Growth Regulation
  • {SNA} A to C,
  • {SNA} A to C, A-AM, Antitumor Agents, Approved Therapeutics/Drug Candidates, Aromatase Inhibitors,
  • {SNA} A to C,

产品应用

  • An aromatase inhibitor. Also blocks adrenal steroidogenesis.

相关文献及参考

  • Santen, R.J. and Misbin, R.I.: Pharmacotherapy, 1, 95 (1981),
  • , Gilman, A.G. and Goodman, L.S., ed. Goodman and Gilman’s The Pharmacological Basis of Therapeutics 9th ed.,, (1996) 9 , 1229, 1274-1275
  • Sun, L., et al., In Vivo Alternative Assessment Of The Chemicals That Interfere With Anterior Pituitary POMC Expression And Interrenal Steroidogenesis In POMC: EGFP Transgenic Zebrafish. Toxicol. Appl. Pharmacol. 248 , 217-25, (2010) 摘要
  • Merck 14 ,440
  • Beil. 22 ,IV,6596
  • Aldrich MSDS 1 , 85:A / Corp MSDS 1 (1), 177:A / FT-IR 2 (2), 3072:B / FT-IR 1 (2), 404:A / FT-NMR 1 (2), 1456:C / RegBook 1 (2), 2079:F / Sigma FT-IR 1 (1), 616:C / Structure Index 1 , 329:B:2

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSMA4026950
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Packing GroupIII
Hazard Class6.1(b)
Storage condition -20°C 2-8°C
UN Number 3249 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 20500 mg/kg/94W-I
TOXIC EFFECTS :
   Blood - agranulocytosis
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   291,970,1985

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 21 mg/kg/3D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   105,633,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 625 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - antipsychotic
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,736,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 3630 mg/kg
SEX/DURATION            : female 1-35 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   AJDCAI American Journal of Diseases of Children.  (AMA, 535 N. Dearborn St.,
   Chicago, IL 60610) V.1-80(3), 1911-50; V.100-    1960-
   Volume(issue)/page/year: 124,421,1972

其他信息

  • 储运特性:库房通风低温干燥
  • MOL 文件:125-84-8.mol
  • 毒性分级:中毒
  • Sigma Aldrich:125-84-8(sigmaaldrich)
  • MSDS 信息:3-(4-Aminophenyl)-3-ethyl-2,6-Piperidinedione(125-84-8).msds
  • TCI Shanghai:DL-氨鲁米特 DL-Aminoglutethimide,>;98.0%(LC)(T)(125-84-8)
  • color:white
  • 急性毒性:腹腔-小鼠LD50:625 毫克/公斤
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • 可燃性危险特性:可燃;燃烧产生有毒氮氧化物烟雾
  • 类别:有毒物品

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. Novartis - Approved Therapeutics/Drug Candidates
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Hormones - Cytokines, Growth Factors and Hormones
  6. Steroid Hormones - Hormones
  7. Other Steroid Products - Steroid Hormones
  1. Functional Group 官能团索引
  2. carboxylic acid imide, N-unsubstituted

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