• S22 Do not breathe dust 不要吸入粉尘；
• S36 Wear suitable protective clothing 穿戴适当的防护服；

• R22 Harmful if swallowed 吞咽有害
• R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用

• P281 Use personal protective equipment as required. 使用所需的个人防护装备。

• H351 Suspected of causing cancer 怀疑致癌
• H302 Harmful if swallowed 吞食有害

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 17,497,1969

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BMDOAI Biomaterials, Medical Devices, and Artificial Organs.  (New York)
   V.1-14, 1973-86.  For publisher information, see BACOEZ.
   Volume(issue)/page/year: 12,1,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 282 mg/kg/63W-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 48,459,1987

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 5 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 10 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 208,69,1988

{h

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - rat Fibroblast
DOSE/DURATION           : 8 mg/L
REFERENCE :
   SCYYDZ Shengzhi Yu Biyun.  Reproduction and Contraception.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980-
    Volume(issue)/page/year: 6(3),20,1986

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 16 mg/kg/4D (Continuous)
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 37,191,1988

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 15 mg/L/1H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Net

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - rat Fibroblast
DOSE/DURATION           : 8 mg/L
REFERENCE :
   SCYYDZ Shengzhi Yu Biyun.  Reproduction and Contraception.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980-
    Volume(issue)/page/year: 6(3),20,1986

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intrauterine
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2500 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 37,85,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE                    : 56600 ug/kg
SEX/DURATION            : male 43 week(s) pre-mating
TOXIC EFFECTS :
   Reproducti

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE                    : 21 mg/kg
SEX/DURATION            : male 75 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 48,459,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 108 mg/kg
SEX/DURATION            : male 9 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 37,191,1988

TYPE OF TEST            : TDLo - L