Cyclochlorotine

CAS 12663-46-6 MFCD01734223

化学结构图

12663-46-6
SMILES: CC[C@@H]1NC(=O)[C@@H]2C(Cl)C(Cl)CN2C(=O)[C@H](CO)NC(=O)C[C@@H](N[C@@H](CO)C(=O)NC1=O)C1C=CC=CC=1

化学属性

Mol. FormulaC24H31Cl2N5O7
Mol. Weight572.50

别名和识别编码

Chemical NameCyclochlorotine
Synonym Chloropeptide Islanditoxin Chlorine-containing peptide, from penicillium islandicum Chloropeptide, from penicillium islandicum Cyclic(L-3-phenyl-beta-alanyl-L-seryl-3,4-dichloro-L-prolyl-L-alpha-aminobutyryl-L-seryl)
CAS Number12663-46-6
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 362 mg/kg/32W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Blood - leukemia
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 10,193,1972

RTECSGU2100000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 335 ug/kg
TOXIC EFFECTS :
   Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring)
REFERENCE :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 475 ug/kg
TOXIC EFFECTS :
   Liver - other changes
   Endocrine - hypoglycemia
   Endocrine - hyperglycemia
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 10,193,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6550 ug/kg
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), zonal
   Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring)
   Liver - other changes
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 10,193,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 ug/kg
TOXIC EFFECTS :
   Vascular - other changes
   Lungs, Thorax, or Respiration - other changes
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 2,349,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBS

{ha

系列性分类

相关产品推荐