Sulfamerazine 磺胺甲基嘧啶

CAS 127-79-7 MFCD00023212

化学结构图

127-79-7
SMILES: Cc1ccnc(NS(=O)(=O)c2ccc(N)cc2)n1

化学属性

Mol. FormulaC11H12N4O2S
Mol. Weight264
Melting Point233
TSCAYes
Density1.3425

别名和识别编码

Chemical NameSulfamerazine, 98%, reference material
CAS Number127-79-7
Synonym {} 4-Amino-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide, N1-(4-Methylpyrimidin-2-yl)sulfanilamide, 2-Sulfanilamido-4-methylpyrimidine Mebacid Methylsulfadiazine Sulfamerazine Trimetox
MDL NumberMFCD00023212
PubChem Substance ID5325
Beilstein Registry Number249133
EC Number204-866-2
Merck Number14,8913
Chemical Name Translation磺胺甲基嘧啶
Wiswesser Line NotationT6N CNJ BMSWR DZ& D1
LabNetwork Molecule IDLN00219698
InChIInChI=1S/C11H12N4O2S/c1-8-6-7-13-11(14-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
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分类

  • {SNA} 1694 Pharmaceuticals & Personal Care Products, Analytical Standards, Analytical/Chromatography, Building Blocks, C9 to C11, Chemical Synthesis, EPA, Heterocyclic Building Blocks, Method and Regulation Specific, Neats, Pyrimidines
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards S - T, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • {SNA} Building Blocks, C9 to C11, Chemical Synthesis, Heterocyclic Building Blocks, Pyrimidines
  • {SNA} Analytical Standa
  • {SNA} 1694 Pharmaceuticals & Personal Care Products, Alphabetical Index of Analytical Standards, Analytical Standards,

产品应用

  • 作用与磺胺嘧啶相似，但对溶血性链球菌和肺炎球菌所引起的感染，具有较高的疗效。适用于肺炎、丹毒、脑膜炎等病。吸收较快，毒性较小。

相关文献及参考

  • Merck: 14,8913
  • Short: EINECS
  • Short: IV/8A
  • Woolfenden, R.D.G., et al.: Anal. Profiles Drug Subs., 6, 515 (1977),

安全信息

RTECSWP0750000
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P317
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P317
  • P337+P317
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany1
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 0-6°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 211,367,1950

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 5,213,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1190 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   27,141,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1890 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   27,141,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 6 gm/kg
SEX/DURATION            : female 6-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 101,362,1951

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 17934 mg/kg
SEX/DURATION            : male 6 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 81,259,1987

其他信息

  • 无臭。味微苦。在空气中无变化。遇日光色渐变深。微溶于水、乙醇和丙酮。易溶于稀无机酸、氢氧化碱溶液或氨水。
  • 储运特性:库房通风低温干燥
  • F:10
  • 急性毒性:皮下-大鼠 LD50: 1890 毫克/公斤; 腹腔-小鼠LD50: 1400 毫克/公斤
  • 毒性分级:中毒
  • 用途一:用作医药中间体
  • 磺胺甲基嘧啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 SS887601 磺胺甲基嘧啶 50g 165.73元 2010/05/25 L04194 磺胺甲基嘧啶, 98+% Sulfamerazine, 98+% 25g 161元 2010/05/25 L04194 磺胺甲基嘧啶, 98+% Sulfamerazine, 98+% 100g 545元
  • 用途二:作用与磺胺嘧啶相似，但对溶血性链球菌和肺炎球菌所引起的感染，具有较高的疗效。适用于肺炎、丹毒、脑膜炎等病。吸收较快，毒性较小。
  • Alfa Aesar:磺胺甲基嘧啶,98+% Sulfamerazine, 98+%(127-79-7)
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • 外观性质:色或淡黄色晶体或结晶粉末。无臭。味微苦。在空气中无变化。遇日光色渐变深。微溶于水、乙醇和丙酮。易溶于稀无机酸、氢氧化碱溶液或氨水。熔点：234~238℃
  • MOL 文件:127-79-7.mol
  • 类别:有毒物品
  • 可燃性危险特性:可燃;燃烧产生有毒氮氧化物和硫氧化物烟雾
  • Sigma Aldrich:127-79-7(sigmaaldrich)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrimidines 嘧啶
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. S - Alphabetic
  5. SN - SZ - S
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrimidines 嘧啶
  5. C9 to C11 - Pyrimidines

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