Ethyl 6-(5-(Phenylsulfonamido)Pyridin-3-Yl)Imidazo[1,2-A]Pyridine-3-Carboxylate 6-(5-(苯基磺酰胺基)吡啶-3-基)咪唑并[1,2-a]吡啶-3-羧酸乙酯
CAS 1276110-06-5 MFCD376110065
化学结构图
SMILES: CCOC(=O)c1cnc2ccc(-c3cncc(NS(=O)(=O)c4ccccc4)c3)cn12
化学属性
| Mol. Weight | 422.46 |
|---|---|
| Appearance | white to off-white solid powder |
| Solubility | soluble in DMSO, not soluble in water. |
别名和识别编码
| Chemical Name Translation | 6-(5-(苯基磺酰胺基)吡啶-3-基)咪唑并[1,2-a]吡啶-3-羧酸乙酯 |
|---|---|
| Chemical Name | Ethyl 6-(5-(Phenylsulfonamido)Pyridin-3-Yl)Imidazo[1,2-A]Pyridine-3-Carboxylate |
| Formula | C21H18N4O4S |
| Synonym | HS173; HS 173; HS-173. |
| IUPAC Name | ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate |
| InChIKey | SEKOTFCHZNXZMM-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H18N4O4S/c1-2-29-21(26)19-13-23-20-9-8-15(14-25(19)20)16-10-17(12-22-11-16)24-30(27,28)18-6-4-3-5-7-18/h3-14,24H,2H2,1H3 |
| Canonical SMILES | O=C(C1=CN=C2C=CC(C3=CC(NS(=O)(C4=CC=CC=C4)=O)=CN=C3)=CN21)OCC |
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产品应用
- HS-173 is a potent PI3Kα inhibitor with potential anticancer activity. HS-173 inhibited the PI3K signaling pathway, and showed anti-proliferative effects on cancer cells. Also, HS-173 induced cell cycle arrest at the G(2)/M phase and apoptosis. In addition, HS-173 decreased the expression HIF-1α and VEGF which play an important role in angiogenesis. This effect was confirmed by the suppression of tube formation and migration assay in vitro. Furthermore, HS-173 diminished blood vessel formation in the Matrigel plug assay in mice. Therefore, HS-173 is considered as a novel drug candidate to treat cancer patients.
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