Ethylamine,N,N-dimethyl-2-(p-(1,2-diphenyl-1-butenyl)phenoxy)-,(E)-

CAS 13002-65-8 MFCD01727016

化学结构图

13002-65-8
SMILES: CC/C(=C(/C1C=CC=CC=1)\C1C=CC(=CC=1)OCCN(C)C)/C1C=CC=CC=1.OC(=O)C(O)(CC(O)=O)CC(O)=O

化学属性

Mol. FormulaC26H29NO
Mol. Weight371.56

别名和识别编码

Chemical NameEthylamine,N,N-dimethyl-2-(p-(1,2-diphenyl-1-butenyl)phenoxy)-,(E)-
CAS Number13002-65-8
Synonym cis-Tamoxifen E-Tamoxifen 2-[4-[(1E)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine Tamoxifen (E) 2-[p-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-ethylamine
Beilstein Registry Number2062021
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分类

  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Protein Kinase Inhibitors and Activators,

产品应用

  • Antineoplastic.

相关文献及参考

  • Bakken, G., et al.: J. Med. Chem., 43, 4534 (2000),

安全信息

RTECSKR5919500 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 4 mg/kg/5D-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Nutritional and Gross Metabolic - dehydration
   Nutritional and Gross Metabolic - changes in calcium
REFERENCE :
   BJCPAT British Journal of Clinical Practice.  (Medical News Group, 1 Bedford
   St., London WC2E 9HD, UK)  V.10(10)-    1956- Volume(issue)/page/year:
   44,716,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 6 mg/kg
SEX/DURATION            : female 1-3 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 41,451,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 225 ug/kg
SEX/DURATION            : female 1-3 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 14,952,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 225 ug/kg
SEX/DURATION            : female 1-3 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 14,952,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        :

系列性分类

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