N-[[Tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide N-[[四氢-4-(4-苯基-2-噻唑基)-2H-吡喃-4-基]甲基]-3-[5-(三氟甲基)-1,2,4-恶二唑-3-基]苯甲酰胺

CAS 1314890-29-3 MFCD414890293

化学结构图

1314890-29-3
SMILES: O=C(NCC1(c2nc(-c3ccccc3)cs2)CCOCC1)c1cccc(-c2noc(C(F)(F)F)n2)c1

化学属性

Mol. Weight514.52
Appearance white to off-white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name TranslationN-[[四氢-4-(4-苯基-2-噻唑基)-2H-吡喃-4-基]甲基]-3-[5-(三氟甲基)-1,2,4-恶二唑-3-基]苯甲酰胺
Chemical NameN-[[Tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide
FormulaC25H21F3N4O3S
Synonym TMP269; TMP 269; TMP-269
IUPAC NameN-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
InChIKeyHORXBWNTEDOVKN-UHFFFAOYSA-N
InChIInChI=1S/C25H21F3N4O3S/c26-25(27,28)22-31-20(32-35-22)17-7-4-8-18(13-17)21(33)29-15-24(9-11-34-12-10-24)23-30-19(14-36-23)16-5-2-1-3-6-16/h1-8,13-14H,9-12,15H2,(H,29,33)
Canonical SMILESO=C(NCC1(C2=NC(C3=CC=CC=C3)=CS2)CCOCC1)C4=CC=CC(C5=NOC(C(F)(F)F)=N5)=C4
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产品应用

  • TMP269 is a highly potent, selective and cell-permeable class IIa HDAC inhibitor with IC50 of 126 nM, 80 nM, 36 nM and 19 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Neuronal Signaling
  3. HDAC

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