(4S,4S)-2,2-(Propane-2,2’-Diyl)Bis(4-(Tert-Butyl)-4,5-Dihydrooxazole) (S,S)-(-)-2,2’-异亚丙基双(4-叔丁基-2-噁唑啉)

CAS 131833-93-7 MFCD00192243

化学结构图

131833-93-7
SMILES: CC(C)(C1=N[C@H](CO1)C(C)(C)C)C1=N[C@H](CO1)C(C)(C)C

化学属性

Mol. FormulaC17H30N2O2
Mol. Weight294
Melting Point89-91
Density1.04

别名和识别编码

Chemical Name(4S,4S)-2,2-(Propane-2,2’-Diyl)Bis(4-(Tert-Butyl)-4,5-Dihydrooxazole)
Synonym (S,S)-(-)-2,2'-异亚丙基双(4-叔丁基-2-恶唑啉) (S,S)-2,2′-Isopropylidene-bis(4-tert-butyl-2-oxazoline) (S,S)-2,2′-异亚丙基-双(4-叔丁基-2-噁唑啉)
MDL NumberMFCD00192243
PubChem Substance ID87571911
CAS Number131833-93-7
Reaxys-RN4296341
Beilstein Registry Number2384789
EC Number250-023-7
Chemical Name Translation(S,S)-(-)-2,2’-异亚丙基双(4-叔丁基-2-噁唑啉)
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分类

  • Asymmetric Synthesis, BOX, Chemical Synthesis, Chiral Catalysts, Ligands, and Reagents, Privileged Ligands and Complexes
  • {SNA} Asymmetric Synthesis, BOX, Chemical Synthesis, Chiral Catalysts, Ligands, and Reagents, Privileged Ligands and Complexes

产品应用

  • 不对称合成的手性催化剂。对映选择性催化反应的 C2 对称配体。由于噁唑啉氮具有对各种金属的强亲合性，因?此容易形成双齿配位络合物。

相关文献及参考

  • 1. Gant, T.G. Meyers, A.I. Tetrahedron 50 , 2297, (1994)
  • 2. Pfaltz, A. Acc. Chem. Res. 26 , 339, (1993)
  • 3. Bolm, C. Angew. Chem. Int. Ed. Engl. 30 , 542, (1991)
  • 4. Tetrahedron Lett. 45 , 4213-4216, (2004)
  • 5. Tetrahedron 60 , 4989-4994, (2004)
  • Tetrahedron Lett. 44 , 7849-7850, (2003)
  • Chem. Eur. J. 10 , 2133-2137, (2004) 摘要
  • Org. Biomolecular Chem. 2 , 1077-1085, (2004) 摘要
  • Fieser 16 ,38 / Fieser 17 ,43
  • FT-IR 2 (1), 1396:D / Structure Index 1 , 150:D:8

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Signal word Warning {} {} {} {} {} {} {} {} {} {} {TCI}
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 储存温度2-8℃

系列性分类

  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Oxazolines/Oxazolidines 恶唑啉/恶唑烷
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Heterocyclic Building Blocks - Chiral Building Blocks
  5. Oxazolines/Oxazolidines - Heterocyclic Building Blocks
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Catalysts, Ligands, and Reagents - Asymmetric Synthesis
  4. Privileged Ligands and Complexes - Chiral Catalysts, Ligands, and Reagents
  5. BOX - Privileged Ligands and Complexes
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Catalysts, Ligands, and Reagents - Asymmetric Synthesis
  4. Privileged Ligands and Complexes - Chiral Catalysts, Ligands, and Reagents
  5. BOX - Privileged Ligands and Complexes
  1. Functional Group 官能团索引
  2. imido ester

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