Phenoxymethylpenicillinic Acid Potassium 青霉素V钾

CAS 132-98-9 MFCD00051771

化学结构图

132-98-9
SMILES: CC1(C)S[C@@H]2[C@H](NC(=O)COc3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[K+]

化学属性

Mol. FormulaC16H17N2O5S.K
Mol. Weight388
Melting Point197-202 ºC
Density1.4

别名和识别编码

Chemical NamePhenoxymethylpenicillinic Acid Potassium
CAS Number132-98-9
Synonym Calciopen K antibiocin 3,3-二甲基-7-氧代-6-(2-苯氧基乙酰胺基)-4-硫-1-氮杂双环[3.2.0]庚烷-2-羧酸钾盐 Beromycin (penicillin) Penicilli PENICILLIN V POTASSIUM 6-(Phenoxyacetamido Penicillin V potassium salt Phe abicyclo[3.2.0]heptane-2-carboxylate (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Potassium 青霉素V钾盐 Potassium penicillin V Distakaps V-K PHENOXYMETHYLPENICILLINIC ACID POTASSIUM SALT Dowpen V-K Po PENICILLIN VK Distaquaine V-K PHENOXYMET Pen-Vee-K powder 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3,3-dimethyl Beromycin betapen-vk Phenoxymethylpenicillin potassium PENICILLINE V POTASSIUM SALT Penvikal Antibiocin Pen-V-K powder SK-Penicillin VK aspinvk Oracil-VK Vepen Phenoxymethylpenicillinic acid potassium salt Megacillin oral arcacil PENICILLIN V P Apsin VK 青霉素V钾 Roscopenin PHENOXYMETHYLPENICILLIN K+ SALT Phenoxymethylpenicillin potassium salt; 3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetamido)-4-thia-1 青霉素 V 钾盐 Veetids beromycin(penicillin) Penicillin V potassium salt PHENOXYMETHYLPENICILLIN POTASSIUM Rocillin-VK Cliacil Compocillin-VK Pen-Vee-K Fenoxypen 3,3-dimethyl-7-oxo-6-(2-phenoxy-acetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid monopotassium salt Betapen-VK {ha
Beilstein Registry Number3899451
PubChem Substance ID23676814
EC Number205-086-5
MDL NumberMFCD00051771
Chemical Name Translation青霉素V钾
InChIKeyHCTVWSOKIJULET-LQDWTQKMSA-M
Wiswesser Line NotationT45 ANV ESTJ CMV1OR& F1 F1 GVQ &-KA-
InChIInChI=1S/C16H18N2O5S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
LabNetwork Molecule IDLN01306709
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分类

  • {SNA} 1694 Pharmaceuticals & Personal Care Products, Alphabetical Index of Analytical Standards, Analytical Standards, Antibiotics, Bactericidal, Chemical Structure, Chromatography, Clinical Standards, EPA, Method and Regulation Specific, Neats, P, PA - PEN, Principle, beta-Lactam Structure, 分析/色谱
  • {SNA} 1694 Pharm
  • {SA} Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Chemical Structure Class, Interferes with Cell Wall Synthesis, L - Z, Mechanism of Action, Penicillins and Cephalosporins (beta-Lactams),
  • 1694 Pharmaceutical

产品应用

  • Antibacterial.

相关文献及参考

  • Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),
  • Dunham, J.M., et al.: Anal. Profiles Drug Subs., 1, 249 (1972),
  • Merck 14 ,7100

安全信息

Precautionary statements
  • P342+P311
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
RTECSXH9275000
GHS Symbol
Signal word
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H302 Harmful if swallowed 吞食有害
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
Hazard Codes Xn
WGK Germany3
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R42/43
Storage condition 2-8°C 2-8℃ 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1351 mg/kg

{hazard_c

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 12,751,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,661,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,661,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1040 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971

TYPE OF TEST

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 9 gm/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-336,1988

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 500 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-336,1988

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 3 gm/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 4,439,1989

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 250 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   12(Suppl 13),103,1988

其他信息

  • MSDS 信息:Penicillin V potassium salt(132-98-9).msds
  • Sigma Aldrich:132-98-9(sigmaaldrich)
  • MOL 文件:132-98-9.mol
  • 用途一:用作抗生素

系列性分类

  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics N-S - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Antibiotics A to Z - Antibiotics
  4. Antibiotics N-S - Antibiotics A to Z
  1. Life Science 生命科学
  2. Antibiotics 抗生素
  3. Mechanism of Action - Antibiotics
  4. Interferes with Cell Wall Synthesis - Mechanism of Action
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. P - Alphabetic
  5. PA - PEN - P
  1. Functional Group 官能团索引
  2. carboxylic acid salt
  1. Functional Group 官能团索引
  2. hemithioaminal

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