Candesartan 坎地沙坦

CAS 139481-59-7 MFCD00864463

化学结构图

139481-59-7
SMILES: CCOC1=NC2C=CC=C(C=2N1CC1C=CC(=CC=1)C1=CC=CC=C1C1NN=NN=1)C(O)=O

化学属性

Mol. FormulaC24H20N6O3
Mol. Weight440
Melting Point155-161

别名和识别编码

Chemical NameCandesartan
CAS Number139481-59-7
Alfabeta NameTETRAZOLYLBIPHENYLYLMETHYLETHOXYBENZOIMIDAZOLECARBOXYLICACID HHD1215114217[[]]((()))---------------,''
MDL NumberN/A
Synonym 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid
Chemical Name Translation坎地沙坦
信息真实价格透明    资金保障    专业采购外包团队在线服务   
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分类

  • Aromatics
  • Heterocycles
  • Nucleotides
  • Bases & Related Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • An angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure. Antihypertensive.

相关文献及参考

  • [2]. Nishimura Y, et al. Chronic peripheral administration of the angiotensin II AT(1) receptor antagonist candesartan blocks brain AT(1) receptors. Brain Res. 2000 Jul 14;871(1):29-38.
  • Kaur, N., et al.: Bioorg. Med. Chem., 16, 10210 (2008),
  • [1]. Pfeffer MA, et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet. 2003 Sep 6;362(9386):759-66.
  • [1]. Pfeffer MA, et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet. 2003 Sep 6;362(9386):759-66.
  • [2]. Nishimura Y, et al. Chronic peripheral administration of the angiotensin II AT(1) receptor antagonist candesartan blocks brain AT(1) receptors. Brain Res. 2000 Jul 14;871(1):29-38.

安全信息

Warnings IRRITANT
GHS Symbol
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
RTECSDD6671000

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Angiotensin Receptor  (血管紧张素受体)

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