N1-(2-(Dimethylamino)Ethyl)-5-Methoxy-N1-Methyl-N4-(4-(1-Methyl-1H-Indol-3-Yl)Pyrimidin-2-Yl)Benzene-1,2,4-Triamine N1-[2-(二甲基氨基)乙基]-5-甲氧基-N1-甲基-N4-[4-(1-甲基-1H-吲哚-3-基)-2-嘧啶基]-1,2,4-苯三胺
CAS 1421372-66-8 MFCD521372668
化学结构图
SMILES: COc1cc(N(C)CCN(C)C)c(N)cc1Nc1nccc(-c2cn(C)c3ccccc23)n1
化学属性
| Mol. Weight | 445.56 |
|---|---|
| Appearance | brown solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | N1-(2-(Dimethylamino)Ethyl)-5-Methoxy-N1-Methyl-N4-(4-(1-Methyl-1H-Indol-3-Yl)Pyrimidin-2-Yl)Benzene-1,2,4-Triamine |
|---|---|
| Chemical Name Translation | N1-[2-(二甲基氨基)乙基]-5-甲氧基-N1-甲基-N4-[4-(1-甲基-1H-吲哚-3-基)-2-嘧啶基]-1,2,4-苯三胺 |
| Formula | C25H31N7O |
| Synonym | AZD9291DA HCl salt; AZD9291 DA; AZD9291-DA; AZD9291-DA hydrochloride |
| IUPAC Name | N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine hydrochloride |
| InChIKey | HTNTZPBKKCORTP-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H31N7O/c1-30(2)12-13-31(3)23-15-24(33-5)21(14-19(23)26)29-25-27-11-10-20(28-25)18-16-32(4)22-9-7-6-8-17(18)22/h6-11,14-16H,12-13,26H2,1-5H3,(H,27,28,29) |
| Canonical SMILES | NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
产品应用
- AZD9291-DA is a des acryl analogue of AZD9291, which is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. It inhibits both activating and resistant EGFR mutations while sparing the normal form of EGFR that is present in normal skin and gut cells, thereby reducing the side effects encountered with currently available medicines.
京ICP备2020036287号