2-[[(3α,5β,7β)-3,7-Dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic acid 2-[[(3α,5β,7β)-3,7-二羟基-24-氧化胆碱-24-基]氨基]乙磺酸

CAS 14605-22-2 MFCD00065451

化学结构图

14605-22-2
SMILES: [Na+].C[C@@H](CCC(=O)NCCS([O-])(=O)=O)[C@@H]1CC[C@@H]2[C@@H]3[C@@H](CC[C@]21C)[C@]1(C)CC[C@H](O)C[C@@H]1C[C@@H]3O |&1:2,14,17,18,19,22,24,28,31,33|

化学属性

Mol. FormulaC26H44NO6SNa
Mol. Weight521.69
Density1.216

别名和识别编码

Chemical Name2-[[(3α,5β,7β)-3,7-Dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic acid
Synonym 2-(((3-alpha,5-beta,7-beta)-3,7-Dihydroxy-24-oxocholan-24-yl)amino)ethanesulfonic acid 3α,7β-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide 3α,7β-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide Tauroursodeoxycholic acid sodium salt Sodium tauroursodeoxycholate Taurine, N-(3-alpha,7-beta-dihydroxy-5-beta-cholan-24-oyl)-, Tauroursodeoxycholic acid Tauroursodeoxycholic acid sodium salt 牛磺熊去氧胆酸;牛磺酸熊脱氧胆酸 牛磺脱氧胆酸
MDL NumberMFCD00065451
PubChem Substance ID24899875
CAS Number14605-22-2
Chemical Name Translation2-[[(3α,5β,7β)-3,7-二羟基-24-氧化胆碱-24-基]氨基]乙磺酸
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分类

  • {SNA} anionic
  • {SNA} Anionic Detergents, Bile Salts, Cell Biology, Cell Signaling and Neuroscience, Chemical Activators and Inhibitors of ER Stress, Chemical ER Chaperones, Detergents, Detergents N to Z, Detergents by Applications, Drug Delivery-Liposomes, Endoplasmic Reticulum Stress
  • {SNA} Anionic Detergents, Bile Salts, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Chemical Activators and Inhibitors of ER Stress, Chemical ER Chaperones, Detergents, Detergents N to Z, Detergents by Applications, Drug Delivery-Liposomes, Endoplasmic Reticulum Stress
  • {SNA} Anionic Detergents,

相关文献及参考

  • [2]. Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345.
  • [1]. Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92(2):307-16.
  • [1]. Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92(2):307-16.
  • [2]. Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345.

安全信息

WGK Germany2
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 储存温度2-8℃
RTECSKI7372500 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >6 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JKXXAF Japanese Kokai Tokyo Koho Patents.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year:
   #92-235918

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JKXXAF Japanese Kokai Tokyo Koho Patents.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year:
   #92-235918

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JKXXAF Japanese Kokai Tokyo Koho Patents.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year:
   #92-235918

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JKXXAF Japanese Kokai Tokyo Koho Patents.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year:
   #92-235918

系列性分类

  1. Application Areas 应用领域分类
  2. Detergents 去污剂洗净剂
  3. Detergents N to Z - Detergents
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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