MELPHALAN

CAS 1465-26-5 MFCD01465265

化学结构图

1465-26-5
SMILES: N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O

化学属性

Mol. FormulaC13H18Cl2N2O2.ClH
Mol. Weight341.69

别名和识别编码

Chemical NameAlanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-,hydrochloride, DL
Chemicalbook IDCB92130920
Wiswesser Line NotationQVYZ1R DN2G2G &GH
Synonym Sarcolysin hydrochloride Merphalan hydrochloride 3-(p-(Bis(2-chloroethyl)amino)phenyl)-DL-alanine hydrochloride DL-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, hydrochloride Sarkoklorin DL-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, monohydrochloride DL-Phenylalanine mustard hydrochloride SKI 21739 Melfalan hydrochloride DL-Phenylalanine, 4-(bis(2-chloroethyl)amino)-, monohydrochloride Melphalan Sarcolysin Sarkolizin Alkeran Sarcolysine DL-Sarcolysine hydrochloride 3-(p-(Bis(beta-chloroethyl)amino)phenyl)-D,L-alanine hydrochloride DL-Sarcolysin monohydrochloride NCS-14210 4-(Bis(2-chloroethyl)amino)-DL-phenylalanine hydrochloride
CAS Number1465-26-5
PubChem Substance ID12312742
InChIInChI=1S/C13H18Cl2N2O2.ClH/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;/h1-4,12H,5-9,16H2,(H,18,19);1H
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安全信息

RTECSAY3980000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 44600 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Gastrointestinal - hypermotility, diarrhea
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year:

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 11(3),28,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 16200 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Gastrointestinal - hypermotility, diarrhea
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 11(3),28,1967

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 20 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 5 mmol/l
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 1200 umol/L
REFERENCE :
   BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
   Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.41-    1956-  Volume(issue)/page/year: 92,943,1981

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent -

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 4 mg/L
REFERENCE :
   NEOLA4 Neoplasma.  (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
      1957-  Vo

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 1 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   38,75,1981

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 1 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   38,75,1981

系列性分类

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