3-METHYL-5-[(2S)-1-METHYL-2-PYRROLIDINYL]ISOXAZOLE HYDROCHLORIDE

CAS 147388-83-8 MFCD11045960

化学结构图

147388-83-8
SMILES: Cl.CC1C=C(ON=1)[C@@H]1CCCN1C

化学属性

Mol. FormulaC9H14N2O · HCl
Mol. Weight202.68

别名和识别编码

Chemical NameABT-418 hydrochloride
Synonym 3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride
MDL NumberMFCD11045960
PubChem Substance ID24724395
CAS Number147388-83-8
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分类

  • {SNA} A-AM, Abbott, Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cholinergics, Diversification Ready Pharma-Developed Compounds, Ion Channels, Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Neurotransmitters, Nicotinic Acetylcholine Receptor Modulators, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • A-AM, Abbott, Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cholinergics, Ion Channels,

相关文献及参考

  • Brioni, J.D., et al., Anxiolytic-like effects of the novel cholinergic channel activator ABT-418 J. Pharmacol. Exp. Ther. 271 , 353-61, (1994)
  • Brioni, J.D., et al., ABT-418: discriminative stimulus properties and effect on ventral tegmental cell activity Psychopharmacology 119 , 368-75, (1995)
  • Nikolov, R., Alzheimer's disease therapy - an update Drug News Perspect. 11 , 248-55, (1998)
  • Papke, R.L. et al. Br. J. Pharmacol. 120 , 429-438, (1997)

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P302+P350
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Signal word Danger
Hazard statements
  • H330 Fatal if inhaled 吸入致命
  • H310 Fatal in contact with skin 皮肤接触致命
  • H300 Fatal if swallowed 吞食致命
Hazard Codes T+
Safety Statements
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S7/9 Keep container tightly closed and in a well-ventilated place 保持容器严格密闭，置于通风良好的场所；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S22 Do not breathe dust 不要吸入粉尘；
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Isoxazoles 异恶唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Oxazoles 恶唑
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Ligand-Gated Ion Channels - Ion Channels
  6. Nicotinic Acetylcholine Receptor Modulators - Ligand-Gated Ion Channels

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