Fluanisone 氟苯丙酮哌嗪

CAS 1480-19-9 MFCD00366636

化学结构图

1480-19-9
SMILES: COc1ccccc1N1CCN(CCCC(=O)c2ccc(F)cc2)CC1

化学属性

Mol. FormulaC21H25FN2O2
Mol. Weight356
Density1.146

别名和识别编码

Chemical NameButyrophenone,4'-fluoro-4-(4-(o-methoxyphenyl)-1-piperazinyl)-
CAS Number1480-19-9
Synonym Fluanisone R 2167 Fluanison 1-Butanone, 1-(4-fluorophenyl)-4-(4-(2-methoxyphenyl)-1-piperazinyl)- Haloanisone Fluanison; Haloanison; Haloanisone; 1-(4-Fluorophenyl)-4-[4-(2-methoxyphenyl)-1-piperazinyl]-1-butanone MD 2028 Anti-Pica Sedalande 4'-Fluoro-4-(4-(o-methoxyphenyl)-1-piperazinyl)butyrophenone 4-(4-(o-Methoxyphenyl)-1-piperazinyl)-p-fluorobutyrophenone ######## 2028 MD R 2028
EC Number216-038-8
Chemical Name Translation氟苯丙酮哌嗪
Wiswesser Line NotationT6N DNTJ A3VR DF& DR BO1
Beilstein Registry Number0707524
LabNetwork Molecule IDLN01296431
PubChem Substance ID15139
InChIInChI=1S/C21H25FN2O2/c1-26-21-7-3-2-5-19(21)24-15-13-23(14-16-24)12-4-6-20(25)17-8-10-18(22)11-9-17/h2-3,5,7-11H,4,6,12-16H2,1H3
MDL Number
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分类

  • Aromatics
  • Heterocycles
  • Neurochemicals
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Fluanisone is a butyrophenone derivative with sedative properties. It is a typical antipsychotic and is used in the treatment of schizophrenia.

相关文献及参考

  • Raevskii, K.S.: Farmakol. Toksikol., 30, 710 (1967); Creese, I. et al.: Science, 192, 481 (1976); Peterson, J. et al.: Physiol. Behav., 60, 759 (1996);

安全信息

RTECSEU3640000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 32,2241,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 550 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   APPHAX Acta Poloniae Pharmaceutica.  For English translation, see APPFAR.
   (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland)  V.1-    1937-
   Volume(issue)/page/year: 40,159,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 420 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Autonomic Nervous System - central sympatholytic
   Behavioral - alteration of classical conditioning
REFERENCE :
   MDCHAG Medicinal Chemistry: A Series of Monographs.  (Academic Press, Inc.,
   1 E. First St., Duluth, MN 55802)  V.1-    1963-  Volume(issue)/page/year:
   4(2),199,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 132 mg/kg
SEX/DURATION            : female 15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.  (ARS Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.25-    1973-  Volume(issue)/page/year:
   32,199,1980

系列性分类

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