(2S,3S,4R,5R)-3,4-Dihydroxy-5-(6-((3-Iodobenzyl)Amino)-9H-Purin-9-Yl)-N-Methyltetrahydrofuran-2-Carboxamide (2S,3S,4R,5R)-3,4-二羟基-5-(6-((3-碘苄基)氨基)-9H-嘌呤-9-基)-N-甲基四氢呋喃-2-甲酰胺

CAS 152918-18-8 MFCD00671785

化学结构图

152918-18-8
SMILES: CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2C(NCC3C=C(I)C=CC=3)=NC=NC1=2

化学属性

Mol. FormulaC18H19IN6O4
Mol. Weight510.29

别名和识别编码

Chemical Name(2S,3S,4R,5R)-3,4-Dihydroxy-5-(6-((3-Iodobenzyl)Amino)-9H-Purin-9-Yl)-N-Methyltetrahydrofuran-2-Carboxamide
Synonym 1-Deoxy-1-[6-[((3-Iodophenyl)methyl)amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide 1-Deoxy-1-[6-[((3-Iodophenyl)methyl)amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide N6-(3-Iodobenzyl)adenosine-5'-N-methyluronamide IB-MECA N6-(3-Iodobenzyl)adenosine-5'-N-methyluronamide
MDL NumberMFCD00671785
PubChem Substance ID24277717
CAS Number152918-18-8
Chemical Name Translation(2S,3S,4R,5R)-3,4-二羟基-5-(6-((3-碘苄基)氨基)-9H-嘌呤-9-基)-N-甲基四氢呋喃-2-甲酰胺
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分类

  • {SNA} Adenosines/P2 Nucleotide Receptors (Purinergics), Agonists, Neuroscience, Neurotransmission, Neurotransmitters, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Adenosines/P2 Nucleotide Receptors (Purinergics), Agonists, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,

相关文献及参考

  • [2]. Abedi H, et al. Mitochondrial and caspase pathways are involved in the induction of apoptosis by IB-MECA in ovarian cancer cell lines. Tumour Biol. 2014 Nov;35(11):11027-11039.
  • [3]. Hofer M, et al. Agonist of the adenosine A3 receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of γ-irradiated mice. Radiat Environ Biophys. 2014 Mar;53(1):211-215.
  • [4]. Chandan Sarkar, et al. Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives. Front Pharmacol. 2020; 11: 572870.
  • [1]. Shin Y, et al. Activation of Phosphoinositide Breakdown and Elevation of Intracellular Calcium in a Rat RBL-
  • [1]. Shin Y, et al. Activation of Phosphoinositide Breakdown and Elevation of Intracellular Calcium in a Rat RBL-2H3 Mast Cell Line by Adenosine Analogs: Involvement of A(3)-Adenosine Receptors? Drug Dev Res. 1996 Sep 1;39(1):36-46.

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. I - Bioactive Small Molecules
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adenosine Receptor  (腺苷受体)

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