LG100268 LG100268

CAS 153559-76-3 MFCD01758574

化学结构图

153559-76-3
SMILES: CC1C=C2C(=CC=1C1(CC1)C1C=CC(=CN=1)C(O)=O)C(C)(C)CCC2(C)C

化学属性

Mol. FormulaC24H29NO2
Mol. Weight363.49

别名和识别编码

Chemical NameLG100268
CAS Number153559-76-3
Synonym 2-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)cyclopropyl]pyridine-5-carboxylic acid AGN 192620 ALRT 268. CD 3127 LG268 LGD 100268 LGD 1268 6-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]-3-Pyridinecarboxylic Acid AGN 192620 ALRT 268 CD 3127 LG 100268 LG 268 LG100268 LGD 100268 LGD 1268
MDL NumberMFCD01758574
PubChem Substance ID329825287
Chemical Name TranslationLG100268
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分类

  • Pharmaceuticals
  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression, PPAR and RXR Regulators
  • Retinoids,
  • Intermediates & Fine Chemicals
  • {SNA} Bioactive Small Molecule Alphabetical Index, Gene Regulation and Expression, L, PPAR and RXR Regulators, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • LG 100268 is a potent RXR agonist for evaluation in the treatment of non-insulin-dependent (type II) diabetes mellitus (NIDDM).

相关文献及参考

  • [2]. D S Lala, et al. Activation of Specific RXR Heterodimers by an Antagonist of RXR Homodimers.Nature. 1996 Oct 3;383(6599):450-3.
  • [3]. Martine Cao,et al.The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice. Cancer Prev Res (Phila). 2016 Jan;9(1):105-14.
  • Clyne, C., et al.: J. Biol. Chem., 277, 20591 (2002),
  • Falender, A., et al.: Endocrinology, 144, 3598 (2003),
  • Santen, R., et al.: J. Clin. Endocrinol. Metab., 87, 3007 (2002),
  • [1]. M F Boehm, et al. Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells. J Med Chem
  • [1]. M F Boehm, et al. Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells. J Med Chem
  • [2]. D S Lala, et al. Activation of Specific RXR Heterodimers by an Antagonist of RXR Homodimers.Nature. 1996 Oct 3;383(6599):450-3.
  • [3]. Martine Cao,et al.The

安全信息

WGK Germany3
RTECSUS5921500

系列性分类


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