N-(5-chloro-1-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-6-(methylimino)-5-(trifluoromethyl)-1,6-dihydropyrimidin-2-amine N2-(5-氯-1-(反式-3-氟-1-(氧杂环丁烷-3-基)哌啶-4-基)-1H-吡唑-4-基)-N4-甲基-5-(三氟甲基)嘧啶-2,4-二胺

CAS 1536200-31-3 MFCD636200313

化学结构图

1536200-31-3
SMILES: CNc1nc(Nc2cnn([C@@H]3CCN(C4COC4)C[C@H]3F)c2Cl)ncc1C(F)(F)F

化学属性

Mol. Weight449.83
Appearance white to off-white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameN-(5-chloro-1-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-6-(methylimino)-5-(trifluoromethyl)-1,6-dihydropyrimidin-2-amine
FormulaC17H20ClF4N7O
Synonym GNE9605; GNE-9605; GNE 9605.
IUPAC NameN2-(5-chloro-1-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine.
InChIKeyPUXPEQJKNAWNQA-DGCLKSJQSA-N
InChIInChI=1S/C17H20ClF4N7O/c1-23-15-10(17(20,21)22)4-24-16(27-15)26-12-5-25-29(14(12)18)13-2-3-28(6-11(13)19)9-7-30-8-9/h4-5,9,11,13H,2-3,6-8H2,1H3,(H2,23,24,26,27)/t11-,13-/m1/s1
Canonical SMILESFC(C1=CN=C(NC2=C(Cl)N([C@H]3[C@H](F)CN(C4COC4)CC3)N=C2)N=C1NC)(F)F
Chemical Name TranslationN2-(5-氯-1-(反式-3-氟-1-(氧杂环丁烷-3-基)哌啶-4-基)-1H-吡唑-4-基)-N4-甲基-5-(三氟甲基)嘧啶-2,4-二胺
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产品应用

  • GNE-9605 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. Leucine-rich repeat kinase 2 (LRRK2) has drawn significant interest in the neuroscience research community because it is one of the most compelling targets for a potential disease-modifying Parkinson's disease therapy.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Autophagy
  3. LRRK2

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