(E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione 伊曲茶碱

CAS 155270-99-8 MFCD00928421

化学结构图

155270-99-8
SMILES:

化学属性

Mol. FormulaC20H24N4O4
Mol. Weight384.43

别名和识别编码

Chemical Name(E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione
Synonym (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methylxanthine 8-[(1E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione KW-6002 Istradefylline
MDL NumberMFCD00928421
Chemical Name Translation伊曲茶碱
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分类

  • {SNA} Adenosines/P2 Nucleotide Receptors (Purinergics), Antagonists, Cell Biology, Cell Signaling and Neuroscience, Neuroscience, Neurotransmission, Neurotransmitters, New Products
  • {SNA} Adenosines/P2 Nucleotide Receptors (Purinergics), Antagonists, Bioactive Small Molecule Alphabetical Index, I, Neuroscience, Neurotransmission, Neurotransmitters, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

相关文献及参考

  • [2]. Shiozaki S, et al. Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP. Psychopharmacology (Berl). 1999 Nov;147(1):90-5.
  • [3]. Kanda T, et al. Combined use of the adenosine A(2A) antagonist KW-6002 with L-DOPA or with selective D1 or D2 dopamine agonists increases antiparkinsonian activity but not dyskinesia in MPTP-treated monkeys. Exp Neurol. 2000 Apr;162(2):321-7.
  • [4]. Brambilla R, et al. Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes. Glia. 2003 Aug;43(2):190-4.
  • [5]. Mihara T, et al. Pharmacological characterization of a novel, potent adenosine A1 and A2A receptor dual antagonist, 5-[5-amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), in models of Parkinson's disease and cognition. J Pharm
  • [1]. Chen JF, et al. Neuroprotection by caffeine and

安全信息

Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
GHS Symbol
Precautionary statements
  • P301+P310
WGK Germany3
Signal word Danger
Hazard Codes T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Adenosines/P2 Nucleotide Receptors (Purinergics) - Neurotransmitters
  8. Antagonists - Adenosines/P2 Nucleotide Receptors (Purinergics)
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adenosine Receptor  (腺苷受体)

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