CAS 1626387-80-1 MFCD726387801-(R)-4-((3-Chloro-2-Fluorophenyl)Amino)-7-Methoxyquinazolin-6-Yl 2,4-Dimethylpiperazine-1-Carboxylate (R)-4-((3-氯-2-氟苯基)氨基)-7-甲氧基喹唑啉-6-基-2,4-二甲基哌嗪-1-羧酸酯 -LabNovo

SMILES: COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC(=O)N1CCN(C)C[C@H]1C

Mol. Weight	459.91
Appearance	white to off-white solid powder
Solubility	Soluble in DMSO, not in water

Chemical Name Translation	(R)-4-((3-氯-2-氟苯基)氨基)-7-甲氧基喹唑啉-6-基-2,4-二甲基哌嗪-1-羧酸酯
Chemical Name	(R)-4-((3-Chloro-2-Fluorophenyl)Amino)-7-Methoxyquinazolin-6-Yl 2,4-Dimethylpiperazine-1-Carboxylate
Formula	C22H23ClFN5O3
Synonym	AZD3759; AZD-3759; AZD 3759; zorifertinibum; zorifertinib.
IUPAC Name	(R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate
InChIKey	MXDSJQHFFDGFDK-CYBMUJFWSA-N
InChI	InChI=1S/C22H23ClFN5O3/c1-13-11-28(2)7-8-29(13)22(30)32-19-9-14-17(10-18(19)31-3)25-12-26-21(14)27-16-6-4-5-15(23)20(16)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H,25,26,27)/t13-/m1/s1
Canonical SMILES	O=C(N1[C@H](C)CN(C)CC1)OC2=CC3=C(NC4=CC=CC(Cl)=C4F)N=CN=C3C=C2OC

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

AZD3759 is also known as zorifertinib. It is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR-mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR-overexpressing cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

相关产品推荐