Hydrazine, 1-acetyl-2-picolinoyl-

CAS 17433-31-7 MFCD00666699

化学结构图

17433-31-7
SMILES: CC(=O)NNC(=O)C1=CC=CC=N1

化学属性

Mol. FormulaC8H9N3O2
Mol. Weight179.20

别名和识别编码

Chemical NameHydrazine, 1-acetyl-2-picolinoyl-
Wiswesser Line NotationT6NJ BVMMV1
Synonym 1-Acetyl-2-picolinoylhydrazine 1-Acetyl-2-picolinolhydrazine 2-Pyridinecarboxylic acid, 2-acetylhydrazide NCI-C04739 NSC-68626 P-2292 Azapicyl N-Acetyl-N'-isonicotinyl hydrazide
Beilstein Registry Number0392704
CAS Number17433-31-7
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安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9750 mg/kg/26W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   RRCRBU Recent Results in Cancer Research.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1965-
   Volume(issue)/page/year: 52,1,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 9750 mg/kg/26W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Reproductive - Tumorigenic effects - ovarian tumors
REFERENCE :
   RRCRBU Recent Results in Cancer Research.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1965-
   Volume(issue)/page/year: 52,1,1975

RTECSMU7700000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 470 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,169,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 673 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - changes in structure or function of salivary glands
   Gastrointestinal - nausea or vomiting
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,169,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 255 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,169,1965

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - nausea or vomiting
REFERENCE :
   NCICP* Progress Report Submitted to the National Cancer Institute by Charles
   Pfizer & Co.  Volume(issue)/page/year: -,169,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE O

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