(R)-Boroleu-(+)-Pinanediol Trifluoroacetate (R)-1-氨基-3-甲基丁基硼酸蒎烷二醇酯三氟乙酸盐

CAS 179324-87-9 MFCD10566030

化学结构图

179324-87-9
SMILES: CC(C)C[C@H](N)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1.O=C(O)C(F)(F)F

化学属性

Mol. FormulaC17H29BF3NO4
Mol. Weight379.22
Melting Point159-161

别名和识别编码

Chemical Name(R)-Boroleu-(+)-Pinanediol Trifluoroacetate
CAS Number179324-87-9
Synonym (?R,3aS,4S,6S,7aR)-
Alfabeta NameBOROLEUCINEPINANEDIOLESTERTRIFLUOROACETATE RSSRS+1235((()))----,,,
MDL NumberMFCD10566030
Chemical Name Translation(R)-1-氨基-3-甲基丁基硼酸蒎烷二醇酯三氟乙酸盐
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分类

  • Amines
  • Boron Derivatives
  • Chiral Reagents
  • Intermediates
  • {KO} Misc

产品应用

  • Bortezomib (B675700) intermediate. A boronic acid dipeptide derivative as proteasome inhibitors.

相关文献及参考

  • Kisselev, A., et al.: Chem. Biol., 8, 739 (2001),
  • Kisselev, A., et al.: J. Biol. Chem., 278, 35869 (2003),
  • Verdoes, M., et al.: Chem. Biol., 13, 1217 (2006),

安全信息

Warnings IRRITANT
GHS Symbol
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
WGK Germany3

药物吸收、分布、代谢与排泄(ADME)

H-bond Donors
2
H-bond Acceptors
5
Rotatable Bonds
3

系列性分类

  1. Application Areas 应用领域分类
  2. Drug Discovery 新药研发
  3. 保特佐米中间体

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