BMS 214662
CAS 195987-41-8 MFCD95987418
化学结构图
SMILES: N#CC1C=CC2=C(CN([C@@H](CN2CC2=CN=CN2)CC2C=CC=CC=2)S(=O)(=O)C2=CC=CS2)C=1 |&1:9|
化学属性
| Mol. Weight | 489.61 |
|---|---|
| Mol. Formula | C25H23N5O2S2 |
别名和识别编码
| CAS Number | 195987-41-8 |
|---|---|
| Chemical Name | BMS 214662 |
| Synonym | (3R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile (R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2- |
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分类
- Aromatics
- Heterocycles
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds
产品应用
- A potent and selective inhibitor of farnesyltransferase that induces mitochondrial apoptosis in chronic myeloid leukemia stem/progenitor cells, including CD34+38- cells, through activation of protein
相关文献及参考
- [2]. Rose WC, et al. Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor. Cancer Res. 2001 Oct 15;61(20):7507-17.
- Rose, W.C. et al.: Cancer Res., 61, 7507 (2001); Tabernero, J. et al.: J. Clin. Oncol., 23, 2521 (2005); Pellicano, F. et al.: Blood, 114, 4186 (2009);
- [1]. Hunt JT, et al. Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity. J Med Chem. 2000 Oct 5;43(20):3587-95.
- [1]. Hunt JT, et al. Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity. J Med Chem. 2000 Oct 5;43(20):3587-95.
- [2]. Rose WC, et al. Preclinical antitumor activity of BMS-214662, a high
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