1-[6-(4-Chlorophenoxy)Hexyl]-3-Cyano-2-Pyridin-4-Ylguanidine 1-(6-(4-氯苯氧基)己基)-3-氰基-2-(吡啶-4-基)胍

CAS 200484-11-3 MFCD00484113

化学结构图

200484-11-3
SMILES:

化学属性

Mol. FormulaC19H22ClN5O

别名和识别编码

Chemical Name1-[6-(4-Chlorophenoxy)Hexyl]-3-Cyano-2-Pyridin-4-Ylguanidine
Chemical Name Translation1-(6-(4-氯苯氧基)己基)-3-氰基-2-(吡啶-4-基)胍
Chemicalbook IDCB41463422
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相关文献及参考

  • [2]. Cerna D, et al. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner. J Biol Chem. 2012 Jun 22;287(26):22408-17.
  • [1]. Watson M, et al. The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol Cell Biol. 2009 Nov;29(21):5872-88.
  • [1]. Watson M, et al. The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol Cell Biol. 2009 Nov;29(21):5872-88.
  • [2]. Cerna D, et al. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. NAMPT  (烟酰胺磷酸核糖转移酶)

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