Pemoline 匹莫林

CAS 2152-34-3 MFCD00083197

化学结构图

2152-34-3
SMILES: NC1=NC(=O)C(c2ccccc2)O1

化学属性

Mol. FormulaC9H8N2O2
Mol. Weight176.19
Appearance solid 白色结晶性粉末。熔点256-257℃（分解）。难溶于水、醚、丙酮和稀盐酸。无臭无味。
Melting Point255-256°C

别名和识别编码

Chemical Name4-Oxazolidinone, 2-imino-5-phenyl-
Synonym 2-IMINO-5-PHENYL-4-OXAZOLIDINONE 2-亚氨基-5-苯基-4-噁唑烷酮 Hyton 2-Amino-5-phenyl-1,3-oxazol-4(5H)-one Sigmadyn Pemoline TRADON Pemolina FWH-352 5-Phenyl-2-imino-4-oxazolidinone Yh 1 Okodon Ronyl 培脑灵 苯异妥英 2-amino-5-phenyl-2-oxazolin-4-one PT 360 2-亚氨基-5-苯基-4-恶唑烷酮 Pioxol PHENYLPSEUDOHYDANTOIN A 13397 Pondex Azoxodone 2-amino-5-phenyl-4(5h)-oxazolon Fenoxazol Deltamine Azoksodon 4-OXO-2-IMINO-5-PHENYLOXAZOLIDINE Notair Stimul 2-Imino-5-phenyl-4-oxazolidinone 2-AMINO-5-PHENYL-4-OXAZOLIDINONE 匹莫林 Tradon 4(5H)-Oxazolone, 2-amino-5-phenyl- Nitan 2-inino-5-phenyloxazolidin-4-one Dantromin 2-AMINO-5-PHENYL-4(5H)-OXAZOLONE Kethamed 2-AMIN-5-PHENYL-4(5H)-OXAZOLONE PEMOLINE PN/135 PHENOXAZOLE 2-amino-5-phenyl-2-oxazolin-4-on 2-imino-4-keto-5-phenyltetrahydrooxazole Phenylisohydantoin 2-亚氨基-5-苯基-4-唑烷酮 2-Amino-5-phenyl-4(5H)-oxazolone H 3104 LA 956 Sistra Phenoxazole PHENYLISOHYDANTOIN Endolin 翠雀它明 VOLITAL Centramin CS 293 2-imino-5-phenyl-4-oxazolidinon 4-Oxazolidinone, 2-imino-5-phenyl- 匹吗啉 Juston-wirkstoff Tradone Phenylpseudohydantoin
MDL NumberMFCD00083197
EC Number218-438-8
Chemical Name Translation匹莫林
CAS Number2152-34-3
Wiswesser Line NotationT5OYMV EHJ BUM ER
PubChem Substance ID4723
InChIInChI=1S/C9H8N2O2/c10-9-11-8(12)7(13-9)6-4-2-1-3-5-6/h1-5,7H,(H2,10,11,12)
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Approved Therapeutics/Drug Candidates, Boehringer Ingelheim, Cell Biology, Cell Signaling and Neuroscience, Neurobiology, Neuroscience, Pharmacologicals, Stimulants

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
RTECSRQ2975000
Signal word Warning
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Hazard Codes Xn
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
Restrict {} 精神药品 精麻类化学品 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 373 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PBPSDY Pharmacological and Biochemical Properties of Drug Substances.
   (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC
   20037)  V.1-    1977-  Volume(issue)/page/year: 1,33,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 536 ug/kg
TOXIC EFFECTS :
   Behavioral - wakefulness
   Gastrointestinal - decreased motility or constipation
   Skin and Appendages - sweating
REFERENCE :
   JCPYDR Journal of Clinical Pyschopharmacology.  (Williams & Wilkins Co., 428
   E. Preston St., Baltimore, MD 21202)  V.1-    1981- Volume(issue)/page/year:
   3,331,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 365 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book
   Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23,    1978-88. For
   publisher information, see ZYZAEU.  Volume(issue)/page/year: 18,343,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 365 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   PBPSDY Pharmacological and Biochemical Properties of Drug Substances.
   (American Pha

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 10 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   CAJPBD Proceedings of the Congenital Anomalies Research Association of
   Japan.  (Kyoto, Japan) No.1-    1961-  Volume(issue)/page/year: 3,2,1963

其他信息

  • MSDS 信息:Pemoline(2152-34-3).msds
  • MOL 文件:2152-34-3.mol
  • Sigma Aldrich:2152-34-3(sigmaaldrich)
  • 用途一:该品为中枢神经兴奋药，兴奋作用中咖啡因的20倍，用于治疗脑功能失调症，轻型优郁症及发作性睡病等。但不良反应较多，逐渐被三环及四环类抗忧郁药所替代。大鼠口服LD50为500mg/kg。
  • color:white
  • 上游原料:DL-扁桃酸
  • 方法一:由苯甲醛经与氯仿缩合、水解得到α-羟基苯乙酸，再经酯化、环合而得匹莫林。

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurobiology - Neuroscience
  6. Pharmacologicals - Neurobiology
  7. Stimulants - Pharmacologicals
  1. Functional Group 官能团索引
  2. isourea

相关产品推荐