AZD-6126

CAS 219923-05-4 MFCD19923054

化学结构图

219923-05-4
SMILES: COc1cc2c(c(OC)c1OC)-c1ccc(OP(=O)(O)O)cc1[C@@H](NC(C)=O)CC2

化学属性

Mol. Weight437.38
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameAZD-6126
FormulaC20H24NO8P
Synonym AZD6126; AZD 6126; AZD-6126; ANG453; ANG-453; ANG 453.
IUPAC Name(5S)-5-acetamido-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c][7]annulen-3-yl dihydrogen phosphate
InChIKeyUGBMEXLBFDAOGL-INIZCTEOSA-N
InChIInChI=1S/C20H24NO8P/c1-11(22)21-16-8-5-12-9-17(26-2)19(27-3)20(28-4)18(12)14-7-6-13(10-15(14)16)29-30(23,24)25/h6-7,9-10,16H,5,8H2,1-4H3,(H,21,22)(H2,23,24,25)/t16-/m0/s1
Canonical SMILESO=P(O)(OC1=CC=C(C2=C(OC)C(OC)=C(OC)C=C2CC[C@@H]3NC(C)=O)C3=C1)O
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产品应用

  • AZD6126, also known as ANG-453, a water-soluble phosphate prodrug of N-acetylcolchinol with potential antiangiogenesis and antineoplastic activities. AZD-6126 is an angiogenesis inhibitor and tubulin inhibitor potentially for the treatment of solid tumours. AZD6126 is converted in vivo into N-acetylcolchinol. N-acetylcolchinol binds to and destabilizes the tubulin cytoskeleton of endothelial cells in tumor blood vessels, which may result in tumor endothelial cel apoptosis, the selective occlusion of tumor blood vessels, cessation of tumor blood flow, and tumor necrosis.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. VDA

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