Oteracil Potassium 氧嗪酸钾

CAS 2207-75-2 MFCD00010565

化学结构图

2207-75-2
SMILES: O=C([O-])c1nc(=O)[nH]c(=O)[nH]1.[K+]

化学属性

Mol. FormulaC4 H2 N3 O4 . K
Mol. Weight195.17
Density1.422
Melting Point300
TSCANo
Appearance 白色结晶粉末
Solubility溶于热水。

别名和识别编码

Chemical NamePotassium oxonate
CAS Number2207-75-2
Synonym 1,4,5,6-Tetrahydro-4,6-dioxo-s-triazine-2-carboxylic acid, potassium salt 1,4,5,6-tetrahydro-4,6-dioxo-s-triazine-2-carboxylicacid,potassiumsalt 4,6-Dihydroxy-1,3,5-triazine 4,6-Dihydroxy-1,3,5-triazine-2-carboxylic Acid Potassium Salt 4,6-Dihydroxy-1,3,5-triazine-2-carboxylic acid potassium salt 5-Azaorotic acid, potassium salt 5-azaoroticacid,potassiumsalt Allantoxanic acid potassium salt Allantoxanic acid, potassium salt OTERACIL POTASSIUM OXONIC ACID POTASSIUM SALT OXONIC ACID POTASSIUM SALT 97.5% Oxonic Acid Potassium Salt {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL NumberMFCD00010565
EC Number218-627-5
Beilstein Registry Number24,451
PubChem Substance ID2723920
Merck Number14,6947
Chemical Name Translation氧嗪酸钾
Reaxys-RN4049961
Wiswesser Line NotationT6MVMVNJ FVO &-KA-
LabNetwork Molecule IDLN00189134
InChIInChI=1S/C4H3N3O4.K/c8-2(9)1-5-3(10)7-4(11)6-1;/h(H,8,9)(H2,5,6,7,10,11);/q;+1/p-1
Canonical SMILESO=C(O[K])C1=NC(O)=NC(O)=N1
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分类

  • Pharmaceuticals
  • Heterocycles
  • Intermediates & Fine Chemicals
  • {SNA} Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Triazines

产品应用

  • Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats.It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.

相关文献及参考

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安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSRR4580000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 10800 ug/kg
SEX/DURATION            : female 9-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 6,289,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3 gm/kg
SEX/DURATION            : female 8-9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 6,299,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4500 mg/kg
SEX/DURATION            : female 8-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 6,299,1976

Storage condition +4°C 2-8°C 4℃
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激

其他信息

  • MSDS 信息:4,6-Dihydroxy-1,3,5-triazine-2-carboxylic acid potassium salt(2207-75-2).msds
  • 可燃性危险特性:可燃; 燃烧产生有毒氮氧化物和氧化钾烟雾
  • 毒性分级:高毒
  • 氧嗪酸钾价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 O0164 氧嗪酸钾 Potassium Oxonate 5G 238元 2014/06/02 O0164 氧嗪酸钾 Potassium Oxonate 25G 866元 2010/06/21 168531000 氧嗪酸钾 Oxonic acid, potassium salt 97.5% 100 GR 4718元
  • Sigma Aldrich:2207-75-2(sigmaaldrich)
  • Acros Organics:4,6-二羟基-1，3，5-噻嗪-2-羧酸钾盐 Oxonic acid, potassium salt, 97.50%(2207-75-2)
  • 检测方法:T
  • MOL 文件:2207-75-2.mol
  • 急性毒性:非肠-人 TDL0: 20 毫克/公斤
  • 图谱信息:氧嗪酸钾(2207-75-2)红外图谱(IR2) 氧嗪酸钾(2207-75-2)红外图谱(IR1)
  • 储运特性:库房通风低温干燥; 与食品原料分开存放
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • TCI Shanghai:氧嗪酸钾 Potassium Oxonate,>;98.0%(LC)(T)(2207-75-2)
  • 类别:有毒物品

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Thiophenes 噻吩
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Triazines 三嗪
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Metal Compounds 金属化合物
  1. Functional Group 官能团索引
  2. carboxylic acid salt

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