(Trimethylsilyl)acetic acid 三甲基硅基乙酸

CAS 2345-38-2 MFCD00042651

化学结构图

2345-38-2
SMILES: C[Si](C)(C)CC(=O)O

化学属性

Mol. FormulaC5H12O2Si
Mol. Weight132.23
Flash Point61.5±22.6 °C
TSCAYes
Boiling Point107.5 °C at 760 mmHg
Melting Point39-42°C
Density0.934
Stability对湿度敏感

别名和识别编码

Chemical Name(Trimethylsilyl)Acetic Acid
MDL NumberMFCD00042651
CAS Number2345-38-2
EC Number219-067-4
Beilstein Registry Number1679394
PubChem Substance ID75366
Synonym 2-(Trimethylsilyl)acetic acid {LY} 2-(Trimethylsilyl)acetic acid {} {LY} 2-(Trimethylsilyl)acetic acid {} {} {LY} 2-(Trimethylsilyl)acetic acid {} {} {} {LY} 2-(Trimethylsilyl)acetic acid {} {} {} {} {LY} 2-(Trimethylsilyl)acetic acid {} {} {} {} {} {LY} 2-(Trimethylsilyl)acetic acid {} {} {} {} {} {} {LY} 2-(Trimethylsilyl)acetic acid {} {} {} {} {} {} {} {LY} 2-(Trimethylsilyl)acetic acid {} {} {} {} {} {} {} {} {LY} 2-(Trimethylsilyl)acetic acid {} {} {} {} {} {} {} {} {} {LY} 2-(Trimethylsilyl)acetic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-(Trimethylsilyl)acetic acid {} {} {} {} {} {} {} {} {} {} {} {LY} 2-(Trimethylsilyl)acetic acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-(Trimethylsilyl)acetic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-(Trimethylsilyl)acetic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-(Trimethylsilyl)acetic acid {} {} {} {} {} {} {} {} {} {} {} {}
Chemical Name Translation三甲基硅基乙酸
InChIKeyJDMMZVAKMAONFU-UHFFFAOYSA-N
LabNetwork Molecule IDLN02001946
InChIInChI=1S/C5H12O2Si/c1-8(2,3)4-5(6)7/h4H2,1-3H3,(H,6,7)
Canonical SMILESO=C(O)C[Si](C)(C)C
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分类

  • {SNA} Building Blocks, C1 to C5, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis, Organic Building Blocks

产品应用

  • 用于合成α-三甲基硅烷甲酸羧酸、α,β-不饱和酸和 α-三甲基硅烷-γ-丁内酯；把羰基化合物转化成α,β-不饱和硫醇酯；制备TMS-烯酮。

相关文献及参考

  • Beilstein:4(3)1855
  • Dehydration with DCC and Et3N gives the ketene which is remarkably stable, showing little tendency to dimerize: Synthesis, 568 (1989).
  • The dilithiated derivative can undergo the Peterson olefination reaction (see Appendix 4), to give substituted acrylic acids, with alkyl halides to give alkyl silylacetic acids and with oxiranes to give -lactones: J. Chem. Soc., Chem. Commun., 537 (1975):

安全信息

RTECSAK0843500
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C {LY} 2-8°C Moisture Sensitive {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
GHS Symbol
WGK Germany2
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Hazard Codes Xi
Packing GroupIII
Hazard Class8
UN Number UN3261

其他信息

  • 用途一:用于合成α-三甲基硅烷甲酸羧酸、α,β-不饱和酸和 α-三甲基硅烷-γ-丁内酯；把羰基化合物转化成α,β-不饱和硫醇酯；制备TMS-烯酮。
  • 图谱信息:乙酸三甲基硅(醇)酯 (2345-38-2)核磁图( 1 HNMR) 乙酸三甲基硅(醇)酯 (2345-38-2)红外图谱(IR2) 乙酸三甲基硅(醇)酯 (2345-38-2)核磁图( 13 CNMR) 乙酸三甲基硅(醇)酯 (2345-38-2)质谱(MS) 乙酸三甲基硅(醇)酯 (2345-38-2)红外图谱(IR1)
  • 上游原料:盐酸 --> 乙醚 --> 二氯甲烷 --> 硫酸钠 --> 碳酸氢钠 --> 正丁基锂 --> 三氯化铝 --> N-溴代丁二酰亚胺 --> 正戊烷 --> 四甲基硅烷
  • Sigma Aldrich:2345-38-2(sigmaaldrich)
  • MOL 文件:2345-38-2.mol
  • TSCA:No
  • Alfa Aesar:(三甲基甲硅烷基）乙酸,98+% (Trimethylsilyl)acetic acid, 98+%(2345-38-2)
  • F:3-10-21
  • 敏感性:Moisture Sensitive
  • TCI Shanghai:三甲基硅基乙酸 Trimethylsilylacetic Acid,>;97.0%(T)(2345-38-2)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Organometallic Reagents 金属有机试剂
  3. Organosilicon 有机硅
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Acids - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  6. C1 to C5 - Carboxylic Acids
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Silicon Compounds for Organic Synthesis 硅化合物

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