8-Bromoadenosine 3′,5′-Cyclic Monophosphate 8-溴腺苷-3’,5’-环单磷酸

CAS 23583-48-4 MFCD00075580

化学结构图

23583-48-4
SMILES: NC1=NC=NC2=C1N=C(Br)N2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O

化学属性

Mol. FormulaC10H11BrN5O6P
Mol. Weight408.10
Melting Point254

别名和识别编码

Chemical Name8-Bromoadenosine 3′,5′-Cyclic Monophosphate
Synonym 8-Bromo-cAMP 8-Br-A-3:5-MP
MDL NumberMFCD00075580
PubChem Substance ID24891835
Beilstein Registry Number591930
CAS Number23583-48-4
EC Number245-760-6
Chemical Name Translation8-溴腺苷-3’,5’-环单磷酸
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分类

  • B, Bio
  • {SNA} B, Bioactive Small Molecule Alphabetical Index, Cyclic Nucleotide Metabolism, Cyclic Nucleotides and Analogs, G Proteins and Cyclic Nucleotides, Kinase/Phosphatase Biology, Protein Kinase A (PKA), Serine/Threonine Kinase Activators, Serine/Threonine Kinase Biology, 生物活性小分子, 细胞信号转导和神经科学,
  • {SA} B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, Cyclic Nucleotides and Analogs, G Proteins and Cyclic Nucleotides, Kinase/Phosphatase Biology, Protein Kinase A (PKA), Serine/Threonine Kinase Activators, Serine/Threonine Kinase Biology
  • {SNA} B,

相关文献及参考

  • Lin, H., et al., Cyclin-dependent Kinase 5 Regulates Steroidogenic Acute Regulatory Protein And Androgen Production In Mouse Leydig Cells. Endocrinology 150 , 396-403, (2009) 摘要
  • Bodenstine, T.M., et al., Homotypic Gap Junctional Communication Associated With Metastasis Suppression Increases With PKA Activity And Is Unaffected By PI3K Inhibition. Cancer Res. 70 , 10002-11, (2010) 摘要
  • Meyer, R.B. Jr., and Miller, J.P., Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity. Life Sci. 14 , 1019-1040, (1974)
  • Hei, Y.J., et al., Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs. Mol. Pharmacol. 39 , 233, (1991) 摘要
  • Martin, T.F., and Kowalchyk, J.A., Growth inhibition by adenosine 3',5-monophosphate derivatives does not require 3',5' phosphodiester linkage. Science 213 , 1120-1122, (1981) 摘要
  • Chen, T.C., et al., Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab. Invest. 78 , 165-174, (1998) 摘要
  • RegBook 1 (2), 2481:B / Structure Index 1 , 392:B:3

安全信息

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany3
GHS Symbol
Safety Statements
Precautionary statements

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleoside Analogs - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Synthetic Oligonucleotides and Related Reagents - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Cyclic Nucleotides and Analogs - Cyclic Nucleotide Metabolism
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Cyclic Nucleotides and Analogs - Cyclic Nucleotide Metabolism

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