Imidazole-4-carboxamide, 5-amino-, compd. with oroticacid (1:1), dihydrate 阿卡明

CAS 2574-78-9 MFCD00867162

化学结构图

2574-78-9
SMILES: NC(=O)c1[nH]cnc1N.O.O.O=C(O)c1cc(=O)[nH]c(=O)[nH]1

化学属性

Mol. Weight318.29
Mol. FormulaC9H10N6O5.2H2O
Appearance 白色或类白色结晶性粉末。熔点284-285℃（分解）。微溶于水，溶溶于乙醇、乙醚、氯仿、石油醚等溶剂。遇光变成淡红或浅紫色，溶于稀酸或碱液中，均不稳定。无臭，无味。

别名和识别编码

Chemical NameImidazole-4-carboxamide, 5-amino-, compd. with oroticacid (1:1), dihydrate
Synonym 阿卡明(奥拉米特) 5-Aminoimedazole-4-carboxamideorotate 5-AMINOIMIDAZOLE-4-CARBOXAMIDEOROTATE(ORAZAMIDE) 5-氨基咪唑-4-甲酰胺乳清酸盐 Aicorat dihydrate AICA orotate 4-amino-5-imidazolecarboxamideorotatedihydrate ORAZAMIDE 乳清酸氨咪酰胺 5-aminoimidazole-4-carboxamideorotatedihydrate aicoratdihydrate 氨咪酰胺乳清酸盐 1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid compound with 5-amino-1h-imidazole-4-carboxamide (1:1) oroticacidcompd.with5(or4)-aminoimidazole-4(or5)-carboxamide(1:1)dihy 5-Aminoimidazole-4-carboxamide orotate dihydrate 5-氨基咪唑-4-甲酰胺 2,6-二氧代-4-嘧啶甲酸盐 阿卡明 aicaorotatedihydrate orazamidedihydrate Aica orotate dihydrate 1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid, compound with 5-amino-1H-imidazole-4-carboxamide (1:1) aicamindihydrate Orazamide 5-Aminoimidazole-4-carboxamide orotate imidazole-4-carboxamide,5-amino-,compd.withoroticacid(1:1),dihydrate 4-Amino-5-imidazolecarboxamide orotate dihydrate Aicamin dihydrate 5-aminoimidazole-4-carboxamide orotate 安肝灵 奥拉米特 Orotic acid compd. with 5(or 4)-aminoimidazole-4(or 5)-carboxamide (1:1) 1,2,3,6-Tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid compound with 5-amino-1H-imidazole-4-carboxamide (1:1) 5-氨基咪唑-4-羧酰胺基乳清酸盐
MDL NumberMFCD00867162
Chemical Name Translation阿卡明
CAS Number2574-78-9
EC Number219-923-7
Wiswesser Line NotationT6MVMVJ FVQ &T5M CNJ DVZ EZ
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安全信息

RTECSNI3915000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   YKKKA8 Yakugaku Kenkyu.  Japanese Journal of Pharmacy and Chemistry. (Osaka,
   Japan)  V.1-39, 1929-68.  Discontinued.  Volume(issue)/page/year: 35,94,1963

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   YKKKA8 Yakugaku Kenkyu.  Japanese Journal of Pharmacy and Chemistry. (Osaka,
   Japan)  V.1-39, 1929-68.  Discontinued.  Volume(issue)/page/year: 35,94,1963

其他信息

  • 方法一:4-氨基-5-咪唑羟酰胺-水合物与乳清酸成盐而得。取14.4g4-氨基-5-咪唑羟酰胺单水合物和17.4g乳清酸单水合物加热溶于600ml水中，溶液用活性炭脱色，冷却，然后过滤，得28g白色结晶性阿卡明。
  • 用途二:该品为嘌呤及嘧啶衍生物的前体，参与体内核酸代高谢，纠正蛋白质、脂肪和糖的异常代射。预防肝细胞坏死、纤维化及脂肪肝，并可促进肝细胞的再生，改善白蛋白与球蛋白的比例及血清总旧白水平，使异常的SGPT及黄疸指数获得好转。用于治疗急慢性肝炎、肝硬化、脂肪肝、黄疸病等。
  • 上游原料:咪唑 --> 乳清酸 --> 乳清酸
  • MOL 文件:2574-78-9.mol
  • 用途一:护肝产品

系列性分类

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