N-Formylpiperidine 哌啶-1-甲醛

CAS 2591-86-8 MFCD00006483

化学结构图

2591-86-8
SMILES: O=CN1CCCCC1

化学属性

Mol. FormulaC6H11NO
Mol. Weight113.16
Density1.019
Refractive index1.4820 to 1.4850
Flash Point91°C(lit.)
TSCAYes
Boiling Point222.5 °C at 760 mmHg
Melting Point-31 °C
Vapor Pressure0.1 mmHg ( 25 °C)
Solubility易溶

别名和识别编码

Chemical NameN-Formylpiperidine
CAS Number2591-86-8
Alfabeta NamePIPERIDINECARBALDEHYDE 1-
MDL NumberMFCD00006483
Synonym Piperidine-1-carbaldehyde {LY} Piperidine-1-carbaldehyde {} {LY} Piperidine-1-carbaldehyde {} {} {LY} Piperidine-1-carbaldehyde {} {} {} {LY} Piperidine-1-carbaldehyde {} {} {} {} {LY} Piperidine-1-carbaldehyde {} {} {} {} {} {LY} Piperidine-1-carbaldehyde {} {} {} {} {} {} {LY} Piperidine-1-carbaldehyde {} {} {} {} {} {} {} {LY} Piperidine-1-carbaldehyde {} {} {} {} {} {} {} {} {LY} Piperidine-1-carbaldehyde {} {} {} {} {} {} {} {} {} {LY} Piperidine-1-carbaldehyde {} {} {} {} {} {} {} {} {} {} {LY} Piperidine-1-carbaldehyde {} {} {} {} {} {} {} {} {} {} {} {LY} Piperidine-1-carbaldehyde {} {} {} {} {} {} {} {} {} {} {} {} {LY} Piperidine-1-carbaldehyde {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Piperidine-1-carbaldehyde {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Piperidine-1-carbaldehyde {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Piperidine-1-carbaldehyde {} {} {} {}
EC Number219-986-0
Beilstein Registry Number107697
PubChem Substance ID17429
Chemical Name Translation哌啶-1-甲醛
Reaxys-RN107697
Wiswesser Line NotationT6NTJ AVH
LabNetwork Molecule IDLN00008297
InChIInChI=1S/C6H11NO/c8-6-7-4-2-1-3-5-7/h6H,1-5H2
Canonical SMILESO=CN1CCCCC1
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分类

  • {SNA} Building Blocks, C5 to C7, Chemical Synthesis, Heterocyclic Building Blocks, Piperidines
  • {uni_hamburg} no charge; nitrogen heterocycle; alicycle; 6RingOnly; 6ring; 1fragment

产品应用

  • 用于格氏试剂(Grignard reagents)的甲酰基转移。

相关文献及参考

  • Beilstein:20,45
  • Short: IV/10B
  • Short: IV/10A
  • Reaction with Grignard or alkyllithium reagents gives aldehydes in high yield: Angew. Chem. Int. Ed., 20, 878 (1981); Org. Synth. Coll., 7, 451 (1990).

安全信息

Warnings IRRITANT
Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P352+P312+P361+P364
  • P304+P340+P312
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P332+P313
  • P370+P378
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSTN0380000
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H302 Harmful if swallowed 吞食有害
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H227 Combustible liquid 可燃液体
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes 6.1 Xn
UN Number 2810
Packing GroupIII
Hazard Class6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 840 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0534315

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BDCGAS Berichte der Deutschen Chemischen Gesellschaft.  (Leipzig, Ger. Dem.
   Rep.)  V.1-61, 1868-1928. For publisher information, see CHBEAM.
   Volume(issue)/page/year: 34,2408,1901

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 870 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0534315

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6600 mg/kg
SEX/DURATION            : female 6-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   18,96,1992

Storage condition -20°C, stored under nitrogen {LY} -20°C, stored under nitrogen Store at room temperature {} {LY} -20°C, stored under nitrogen {} {} {LY} -20°C, stored under nitrogen {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitro

其他信息

  • Sigma Aldrich:2591-86-8(sigmaaldrich)
  • MSDS 信息:N-Formylpiperidine(2591-86-8).msds
  • Acros Organics:n-甲酰哌啶 N-Formylpiperidine, 99%(2591-86-8)
  • Alfa Aesar:N-甲酸基哌啶,99% 1-Formylpiperidine, 99%(2591-86-8)
  • 用途一:用于格氏试剂(Grignard reagents)的甲酰基转移。
  • MOL 文件:2591-86-8.mol
  • TCI Shanghai:哌啶-1-甲醛 1-Formylpiperidine,>;98.0%(GC)(2591-86-8)
  • 下游产品:(4-甲酰基吡啶-3-基)氨基甲酸叔丁酯
  • 海关编码:29333999
  • 溶于水,也溶于乙醇、醚和己烷。
  • 图谱信息:哌啶-1-甲醛(2591-86-8)红外图谱(IR1) 哌啶-1-甲醛(2591-86-8)核磁图( 13 CNMR) 哌啶-1-甲醛(2591-86-8)质谱(MS) 哌啶-1-甲醛(2591-86-8)核磁图( 1 HNMR)
  • 蒸气压:0.1 mm Hg ( 25 °C)
  • 外观性质:完全溶于水,也溶于乙醇、醚和己烷。密度:1.019熔点:-31 °C沸点:222 °C折光率:1.484闪点:91 °C
  • 哌啶-1-甲醛价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 F0234 1-甲酰哌啶 1-Formylpiperidine 500ML 1350元 2014/06/02 F0234 1-甲酰哌啶 1-Formylpiperidine 25ML 212元 2010/06/21 119730010 哌啶-1-甲醛 N-Formylpiperidine 99% 1 LT 3125元

系列性分类


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