Naproxen Sodium 萘普生钠

CAS 26159-34-2 MFCD00058507

化学结构图

26159-34-2
SMILES: [Na+].COC1=CC2=CC=C(C=C2C=C1)[C@@H](C)C([O-])=O |&1:13|

化学属性

Mol. FormulaC14H13NaO3
Mol. Weight252
TSCANo
Melting Point259-262°

别名和识别编码

Chemical NameNaproxen Sodium
CAS Number26159-34-2
Synonym (S)-6-甲氧基-α-甲基-2-萘乙酸 钠盐 S-(-)2-(6-甲氧基-2-萘基)丙酸钠 NAPROXEN, USP sodiumnaprosyn {Chemi (S)-6-METHOXY-A-METHYL-2-NAPHTHALENEACETIC ACID, SODIUM SALT l-(-)-6-methoxy-alpha-methyl-2-naphthaleneaceticacidsodiumsalt (S)-NAPROXEN, SODIUM SALT (S)-6-Methoxy-?-methyl-2-naphthaleneacetic Acid Sodium Salt (-)-NAPROXEN SODIUM SALT 6-methoxy-alpha-methyl-,sodiumsalt,(s)-2-naphthaleneaceticaci 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, sodium salt, (R)- NAPROXEN SODIUM naprosynsodium Naproxen sodium USP.CP 溴甲氧基萘R-杂质N sodiumnaproxen 甲氧奈丙酸钠 aleve sodium (-)-2-(6-methoxy-2-naphthyl)propionate 萘普生钠 NAPROXEN SODIUM SALT
MDL NumberMFCD00058507
PubChem Substance ID24897724
EC Number247-486-2
Merck Number14,6417
Chemical Name Translation萘普生钠
InChIKeyCDBRNDSHEYLDJV-FVGYRXGTSA-M
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分类

  • Pharmaceuticals
  • {SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Analytical Standards, Analytical/Chromatography, Chromatography, Naproxen,
  • {SNA} Core Bioreagents, Enzyme Inhibitors, Pharmacopoeia, Pharmacopoeia A-Z, Research Essentials, 分析/色谱
  • {SNA} A to C,

产品应用

  • An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory.

相关文献及参考

  • Harrison, I.T., et al.: J. Med. Chem., 13, 203 (1970)

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
Hazard statements
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H302 Harmful if swallowed 吞食有害
RTECSQJ1047000
Signal word Danger
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Hazard Codes T Xn
Risk Statements
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
  • R22 Harmful if swallowed 吞咽有害
Packing GroupIII
Hazard Class6.1(b)
UN Number 3249 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 600 mg/kg/30D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Kidney, Ureter, Bladder - interstitial nephritis
REFERENCE :
   AJDCAI American Journal of Diseases of Children.  (AMA, 535 N. Dearborn St.,
   Chicago, IL 60610) V.1-80(3), 1911-50; V.100-    1960-
   Volume(issue)/page/year: 142,524,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 500 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 38,238,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 20 mg/kg
SEX/DURATION            : female 2 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 27,505,1983

其他信息

  • 非甾体类抗炎镇痛药:萘普生钠 是较易为人耐受的一种非甾体类抗炎镇痛药，属于苯丙酸类化合物，通过抑制前列腺素的合成而发挥抗炎镇痛作用，口服后吸收迅速，2～4小时内，血浆达到高峰浓度。食物对吸收速率影响不大，萘普生与血浆蛋白高度结合(99%)，血浆浓度23～40mcg/ml之间。代谢为去甲基再与葡糖苷酸结合，消除半衰期12～15小时，主要由尿排出。临床适用于缓解各种轻度至中等度的疼痛，如拔牙及其他手术后的疼痛、原发性痛经及头痛等。也适用于类风湿关节炎、骨关节炎、强直性脊柱炎、幼年型风湿性关节炎（Juvenile arthritis）、肌腱炎、滑囊炎及急性痛风性关节炎，对于关节炎的疼痛、肿胀及活动受限均有缓解症状的作用。银屑病性关节炎和Reiter氏综合征亦可改用本品治疗。与布洛芬、非诺洛芬、阿司匹林、舒林酸和吲哚美辛比较，症状缓解的效应相仿，但胃肠道和神经系统的不良反应的发生率和严重程度均较低。另外本品亦像阿司匹林一样能抑制血小板凝聚，延长出血时间，但为可逆性，停药后即可恢复。 萘普生钠与血浆蛋白的结合率高(99%)，并可将其他与蛋白结合的药物，由其结合部置换出来。故接受这类药物(如口服抗凝剂、磺酰脲、乙内酰脲[hydantoins])的人，应注意观察相互作用。同时应用丙磺舒，可使萘普生的血浆浓度增高，半衰期延长。氢氧化镁、铝可使本品吸收速率稍有减低，重碳酸钠则可使之增高。
  • MOL 文件:26159-34-2.mol
  • 上游原料:萘普生
  • 用途一:用作消炎镇痛药
  • Sigma Aldrich:26159-34-2(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. N - Bioactive Small Molecules
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. C6 - Pyridines
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Cell Signaling Enzymes - Application Index
  6. Cyclooxygenase (COX) Enzymes - Cell Signaling Enzymes
  7. Cyclooxygenase Inhibitors - Cyclooxygenase (COX) Enzymes
  1. Functional Group 官能团索引
  2. carboxylic acid salt

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