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• 试剂商城
• 直接询价

分类

• Azidation/Diazo Transfer, Azide Sources, C-X Bond Formation (Non-Halogen), Chemical Biology, Chemical Synthesis,
• {SNA} Azidation/Diazo Transfer, C-X Bond
• {SNA} Azid
• {SNA} Core Bioreagents, General Reagents, Life Science Reagents for RNAi, Research Essentials
• {SNA} Azidation/Diazo Transfer, C-X Bond Formation (Non-Halogen), Chemical Synthesis,
• {SNA} Azidation/Diazo Transfer, C-X Bond Formation (Non-Halogen), Chemical Synthesis, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Preservatives and Antimicrobials for Protein Stabilization, R to Z, Reagents for Protein Stabilization, Superoxide dismutase, Synthetic Reagents, 生化试剂, 蛋白质及衍生物, 酶、抑制剂和底物

相关文献及参考

• 1. Synth. Commun. 37 , 1027, (2007)
• 2. V. N. Telvekar and K. A. Sasane, Synlett 18 , 2778-2780, (2010)
• 3. X. Sun, et al., Org. Lett. 9 , 4495-4498, (2007) 摘要
• 4. H. Chen, et al., Macromolecules 43 , 3613-3623, (2010)
• 5. D. Cao, et al., Inorg. Chem. 44 , 3599-3604, (2005) 摘要
• 6. G. I. Borodkin, et al., Russ. J. Org. Chem. 40 , 1541-1542, (2004)
• 7. Y. Wada, et al., Tetrahedron 65 , 1059-1062, (2009)
• Merck 14 ,8581
• Corp MSDS 1 (2), 3129:D / FT-IR 1 (2), 1252:B / FT-IR 2 (3), 4724:C / IR-Spectra (3), 1568:B / RegBook 1 (3), 3371:A / Sax 6 , 2412 / Sigma FT-IR 1 (2), 1041:C
• Reagent for selective cleavage of methyldiphenylsilyl ethers; see Diphenyl­methyl­chlorosi
• {A
• The reaction of alkyl halides with the highly-nucleophilic azide anion gives alkyl azides which, because of their facile reduction by hydrogenation, SnCl2, P(III) reagents, etc., provide an excellent, mild route to primary amines. For a review of the preparation and synthetic uses of azides, see: Chem. Rev., 88, 297 (1988). The preparation of alkyl azides is ideally suited to phase-transfer methods: Synthesis, 823 (1979); Tetrahedron Lett., 3107 (1978); 30, 1245 (1989). The use of ultrasound has also been found to be effective: Acta Chem. Scand. B, 38, 895 (1984). For a one-pot conversion of alkyl bromides to amines using the Staudinger reaction, see Triethyl­ phosphite, L00339; see also Triphenyl­phosphine, L02502. For reviews, see: Tetrahedron, 37, 437 (1981); 48, 1353 (1992).
• Reaction with acyl halides or mixed anhydrides gives acyl azides. These undergo the Curtius rearrangement to isocyanates, which can be isolated, or hydrolyzed in situ to the primary amine. For examples, see: Org. Synth. Coll., 6, 95, 910 (1988).

安全信息

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2730 mg/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - tumors
   Skin and Appendages - tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 67,75,1981

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5460 mg/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - tumors
   Skin and Appendages - tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 67,75,1981

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 786 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
   Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
   MTAEEB Medical Toxicology and Adverse Drug Experience.  (Adis International
   Ltd., Private Baq 65901, Mairangi Bay, Auckland 10, N.Z.)  V.4-    1989-
   Volume(issue)/page/year: 4,219,1989

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE

{

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 143 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - somnolence (general depressed activity)
   Behavioral - irritability
REFERENCE :
   JTCTDW Journal of Toxicology, Clinical Toxicology.  (Marcel Dekker, 270
   Madison Ave., New York, NY 10016)  V.19-    1982-  Volume(issue)/page/year:
   24,339,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 19 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of Ne

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 ug/plate
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 72,5135,1975

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 100

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 30 ng/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 9(Suppl
   9),1,1987

TYPE OF TEST            : Heritable translocation test
ROUTE OF EXPOSURE       : Oral

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 77,293,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 33300 ng/plate
REFERENCE :
   ENMUDM Environmenta

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 500 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 389,157,1997

其他信息

• Sigma Aldrich:26628-22-8(sigmaaldrich)
• 用途:用作医药原料，由叠氮化钠制备四唑类化合物，进一步合成抗生素头孢菌素药物，而四唑类化合物还是彩色摄影用药剂。 用作耐热性特殊雷管的起爆剂叠氮化铅的原料。 合成树脂发泡剂。 用作吸收及除去真空管内残余气体。 从20世纪90年代开始叠氮化钠用作汽车司机安全防护袋的气源，紧急刹车时，立即自动充气;其产生气体的原理是： 2NaN3+CuO→Na2O+3N2+Cu 16NaN3+3MoS3+2S→ 8Na2S+3Mo+24N2 10NaN3+2KNO3+SiO2→ 5Na2O·K2O·5SiO2+16N2 用作有机合成原料、农药原料、分析试剂。 用作药品和炸药，也用来制叠氮酸、叠氮酸酯、叠氮化铅和纯的金属钠。 叠氮化钠为照相乳剂的一种防腐剂。可加入乳剂中，或加到中间层及保护层中，不影响乳剂照相性能，具有优良的防腐杀菌性能。
• 水中溶解度(g/100ml):不同温度(℃)时每100毫升水中的溶解克数: 38.9g/0℃;39.9g/10℃;40.8g/20℃
• 上游原料:乙醇 --> 亚硝酸钠 --> 水合肼 --> 正丁醇 --> 水合肼
• 制备方法:1，以金属钠为原料，与氨反应，
• Alfa Aesar:叠氮化钠,99% Sodium azide, 99%(26628-22-8)
• 急性毒性:口服-大鼠 LD50: 27 毫克/公斤; 口服-小鼠 LD50: 27 毫克/公斤
• 可燃性危险特性:遇酸分解易爆炸叠氮酸
• MOL 文件:26628-22-8.mol
• 用途一:用于有机合成、污水含氧量测定、血清防腐剂等
• 图谱信息:叠氮化钠(26628-22-8)红外图谱(IR1)
• 毒性:高毒性，吸入其蒸气，引起头痛、血压下降、支气管炎和虚脱。可经皮吸收。如果每日将叠氮化钠以1mg配成溶液作静脉注射，则血压下降，血管末稍及冠状动脉血管中的血液循环好转，对动脉硬化及麻痹的病症，但是如果误饮浓度为1
• 爆炸物危险特性:与重金属, 重金属盐混合易爆
• 储运特性:轻装轻放; 库房通风、远离明火、高温、阳光; 与氧化剂、易燃物分开存放
• 外观性质:无色六角结晶性粉末。
• MSDS 信息:迭氮(化)钠(26628-22-8).msds
• 叠氮化钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 L1431402 叠氮钠（剧毒） 100g 450元 2011/08/23 L1431403 叠氮钠（剧毒） 500g 1700元 2011/08/23 80115581 叠氮钠(剧毒) 500g 2000元
• 灭火剂:雾状水, 泡沫
• Acros Organics:叠氮化钠 Sodiumazide,extrapure,99%(26628-22-8)
• 理化性质:叠氮化钠 亦称“三氮化钠”，化学式NaN3，分子量65.01，白色六方系晶体，无味，无嗅，纯品无吸湿性。有毒!相对密度1.846。不溶于乙醚，微溶于乙醇(25℃ 时0.3)，溶于液氨(0℃时50.7)和水(0℃时 39、10℃时40.16、100℃时55)。虽然无可燃性，但有爆炸性。加热至40℃分解为氮气和金属钠，并放出大量热。即130.2g的叠氮化钠，可以产生3mol的氮，相当于0℃、101.325×103Pa下67.21体积的氮。与酸反应产生叠氮酸(HN3)，反应化学式如下：2NaN3+H2SO4→Na2SO4+2HN3，叠氮酸从低沸点(37℃)溶液，逐渐增浓，而产生难闻的臭气味，其毒性及爆炸性很强。叠氮化钠能和大多数的碱土金属、一价或多价的重金属的盐类、氢氧化物反应，而生成叠氮化物。特别是铜、
• 下游产品:S-甲基-S-(2-甲基吡嗪基)亚磺酰亚胺 --> 1-甲基-1氢-咪唑-5-异氰酸酯 --> 吲哚-2-羧酸甲酯 --> 1,4-氧硫杂环己烷 亚磺酰亚胺 --> 坎地沙坦 --> 齐多夫定 --> 2,6-二氯-4-吡