H-Asn(β-D-glcnac)-OH H-Asn(glnac-beta-D)-OH
CAS 2776-93-4 MFCD00056071
化学结构图
SMILES: CC(=O)N[C@H]1C(NC(=O)C[C@H](N)C(=O)O)O[C@H](CO)[C@@H](O)[C@@H]1O
化学属性
| Mol. Formula | C12H21N3O8 |
|---|---|
| Mol. Weight | 335.31 |
| Melting Point | 264-266 °C |
| Boiling Point | 818.5±65.0 °C at 760 mmHg |
别名和识别编码
| Chemical Name | H-Asn(β-D-glcnac)-OH |
|---|---|
| Synonym | H-Asn(glcnac-beta-D)-OH {LY} H-Asn(glcnac-beta-D)-OH {} {LY} H-Asn(glcnac-beta-D)-OH {} {} {LY} H-Asn(glcnac-beta-D)-OH {} {} {} {LY} H-Asn(glcnac-beta-D)-OH {} {} {} {} {LY} H-Asn(glcnac-beta-D)-OH {} {} {} {} {} {LY} H-Asn(glcnac-beta-D)-OH {} {} {} {} {} {} {LY} H-Asn(glcnac-beta-D)-OH {} {} {} {} {} {} {} {LY} H-Asn(glcnac-beta-D)-OH {} {} {} {} {} {} {} {} {LY} H-Asn(glcnac-beta-D)-OH {} {} {} {} {} {} {} {} {} {LY} H-Asn(glcnac-beta-D)-OH {} {} {} {} {} {} {} {} {} {} {LY} H-Asn(glcnac-beta-D)-OH {} {} {} {} {} {} {} {} {} {} {} {LY} H-Asn(glcnac-beta-D)-OH {} {} {} {} {} {} {} {} {} {} {} {} {LY} H-Asn(glcnac-beta-D)-OH {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} H-Asn(glcnac-beta-D)-OH {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} H-Asn(glcnac-beta-D)-OH {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} H-Asn(glcnac-beta-D)-OH {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} H-Asn(glcnac-beta-D)-OH {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} |
| MDL Number | MFCD02259695 |
| PubChem Substance ID | 123826 |
| CAS Number | 2776-93-4 |
| Chemical Name Translation | H-Asn(glnac-beta-D)-OH |
| InChIKey | YTTRPBWEMMPYSW-HRRFRDKFSA-N |
| InChI | InChI=1S/C12H21N3O8/c1-4(17)14-8-10(20)9(19)6(3-16)23-11(8)15-7(18)2-5(13)12(21)22/h5-6,8-11,16,19-20H,2-3,13H2,1H3,(H,14,17)(H,15,18)(H,21,22)/t5-,6+,8+,9+,10+,11+/m0/s1 |
| Canonical SMILES | OC([C@@H](N)CC(N[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)NC(C)=O)=O)=O |
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分类
- {SNA} Glycan Component Classes, Glycobiology, N-Glycans, N-Linked Fragments, Post-Translational Modification, Proteomics
- Glycan Component Classes, Glycobiology, N-Glycans, N-Linked Fragments, Post-Translational Modification, Proteomics
- {SNA} Glycan Component Classes, N-Glycans, N-Linked Fragments, 分子生物学, 糖生物学, 翻译后修饰, 蛋白质组学
- {SNA} Glycan Component Classes, Glycobiology, Molecular Biology, N-Glycans, N-Linked Fragments, Post-Translational Modification, Proteomics
相关文献及参考
- Marshall RD., The kinetics of the acid hydrolysis of 2-acetamido-1-N-(β-L-aspartyl)-2-deoxy-β-D-glucopyranosylamine. Biochim. Biophys. Acta 192 , 381-384, (1969)
- Mononen I, Fisher KJ, Kaartinen V, et al., Aspartylglycosaminuria: protein chemistry and molecular biology of the most common lysosomal storage disorder of glycoprotein degradation. FASEB J. 7 , 1247-1256, (1993)
- Risley JM, Huang DH, Kaylor JJ, et al, Glycosylasparaginase activity requires the α-carboxyl group, but not the α-amino group, on N(4)-(2-Acetamido-2-deoxy-β-D-glucopyranosyl)-L-asparagine. Arch. Biochem. Biophys. 391 , 165-170, (2001)
- Risley JM, Huang DH, Kaylor JJ, et al., Glycosylasparaginase inhibition studies: competitive inhibitors, transition state mimics, noncompetitive inhibitors. J. Enzym. Inhib. 16 , 269-274, (2001)
- Dunder U, Valtonen P, et al., Early initiation of enzyme replacement therapy improves metabolic correction in the brain tissue of aspartylglycosaminuria mice. J. Inherit. Metab. Dis. 33 , 611-617, (2010)
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